For procurement professionals and R&D scientists in the pharmaceutical industry, the efficient acquisition of high-quality chemical intermediates is crucial for project success. 6-Chloro-5-(2-chloroethyl)oxindole, identified by CAS number 118289-55-7, is a critical compound, widely used as a key intermediate in the synthesis of important pharmaceuticals, most notably Ziprasidone. This guide provides essential insights for procurement activities related to this intermediate.

Understanding the Product and its Applications

6-Chloro-5-(2-chloroethyl)oxindole is a chemical intermediate with a molecular formula of C10H9Cl2NO and a molecular weight of approximately 230.09 g/mol. It typically appears as a pale pink to yellowish solid. Its primary significance lies in its role as a precursor in the multi-step synthesis of Ziprasidone, an antipsychotic medication. The demand for this intermediate is directly tied to the global demand for Ziprasidone, making its consistent availability and quality a key concern for manufacturers. Researchers also explore its potential in synthesizing other novel drug candidates, leveraging its unique chemical structure.

Key Procurement Considerations: Quality and Purity

When you decide to buy 6-Chloro-5-(2-chloroethyl)oxindole, prioritizing quality is paramount. For pharmaceutical applications, high purity is essential to ensure the efficacy and safety of the final API. Procurement managers should look for suppliers who provide detailed Certificates of Analysis (CoA) that include purity data from reliable analytical methods such as HPLC or GC. Understanding the impurity profile of the intermediate is also important for process development and regulatory compliance. Working with suppliers who can provide consistent batch-to-batch quality is vital for scalable R&D and manufacturing.

Sourcing from China: Advantages and Strategies

China has become a dominant player in the global supply of fine chemicals and pharmaceutical intermediates. When procuring 6-Chloro-5-(2-chloroethyl)oxindole, Chinese manufacturers and suppliers often offer competitive pricing due to economies of scale and manufacturing efficiency. To ensure a successful sourcing strategy:

  • Vet Suppliers Thoroughly: Look for suppliers with established reputations, good manufacturing practices (GMP), and experience in exporting to your region.
  • Request Samples and Quotes: Obtain samples to verify quality and request detailed quotes for the quantities you require.
  • Negotiate Terms: Discuss pricing, payment terms, lead times, and shipping arrangements to ensure they align with your project timelines and budget.
  • Consider Long-Term Partnerships: Building relationships with reliable suppliers can ensure stability and preferred pricing for ongoing needs.

Market Pricing and Availability Trends

The market price of 6-Chloro-5-(2-chloroethyl)oxindole can vary based on factors like global demand, raw material costs, and production capacity. Staying informed about market trends and engaging directly with manufacturers for current pricing is recommended. For bulk purchases, manufacturers in China can often provide significant cost advantages.

In conclusion, securing a consistent and high-quality supply of 6-Chloro-5-(2-chloroethyl)oxindole is critical for pharmaceutical R&D and manufacturing. By adopting a strategic procurement approach, focusing on supplier vetting, quality assurance, and competitive pricing, organizations can effectively source this essential intermediate from leading Chinese manufacturers.