For chemical and pharmaceutical researchers, a deep understanding of the properties and potential applications of key intermediates is vital for successful synthesis and product development. 6-Chloro-5-(2-chloroethyl)oxindole, identified by CAS number 118289-55-7, is a compound that warrants close examination due to its significance in advanced organic synthesis, particularly within the pharmaceutical sector. This guide provides an overview of its chemical profile and its role in driving innovation.

Chemical Structure and Properties

6-Chloro-5-(2-chloroethyl)oxindole has the molecular formula C10H9Cl2NO and a molecular weight of 230.09 g/mol. It typically presents as a white to yellow to orange powder. Key physical and chemical properties reported include a melting point range of 218-221°C and solubility in dimethylformamide. Its IUPAC name is 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one. The presence of chlorine atoms and the oxindole ring system makes it a reactive intermediate, suitable for various synthetic transformations.

Primary Role in Pharmaceutical Synthesis

The most significant application of 6-Chloro-5-(2-chloroethyl)oxindole is its function as a crucial intermediate in the manufacturing of Ziprasidone, an essential medication for treating psychiatric disorders. The precise synthesis of Ziprasidone relies on the consistent purity and availability of this specific precursor. Its chemical structure allows for the necessary coupling reactions to build the final API molecule. For pharmaceutical companies and contract manufacturing organizations (CMOs), securing a reliable supply of this compound from qualified manufacturers is critical for uninterrupted production.

Exploring Broader Applications and Research Potential

Beyond its established role, the chemical scaffold of 6-Chloro-5-(2-chloroethyl)oxindole makes it a compound of interest for broader research initiatives. Medicinal chemists may utilize it as a starting material for developing novel drug candidates targeting various diseases. Its structural similarity to other biologically active compounds suggests potential applications in areas such as oncology or anti-inflammatory research. For those seeking to buy this compound for exploratory synthesis, understanding its reactivity and potential transformation pathways is key.

Sourcing High-Quality Intermediates from China

The global supply chain for fine chemicals often leads to China, a country with a well-developed chemical manufacturing sector. When sourcing 6-Chloro-5-(2-chloroethyl)oxindole, researchers and procurement specialists benefit from the competitive pricing and substantial production capacities available from Chinese suppliers. It is essential to partner with manufacturers who provide detailed product specifications, including purity data (e.g., GC or HPLC analysis), and are compliant with international quality standards. Engaging with experienced suppliers ensures that the material procured meets the rigorous demands of pharmaceutical research and development.

In conclusion, 6-Chloro-5-(2-chloroethyl)oxindole is a valuable intermediate with significant implications for the pharmaceutical industry. Its well-defined chemical properties and critical role in API synthesis make it a compound of continuous interest. By leveraging the expertise and capacity of Chinese manufacturers, researchers can ensure they have access to a reliable and high-quality source of this essential chemical building block.