For procurement managers and research scientists in the pharmaceutical and fine chemical industries, sourcing high-quality intermediates is paramount. Among these critical compounds is 2,6-Difluoropyridine-3-boronic acid (CAS 136466-94-9). This pyridine analogue, characterized by its fluorine atoms and boronic acid moiety, is an indispensable building block for complex organic syntheses. Understanding its properties, synthesis, and reliable procurement channels can significantly streamline your research and production processes.

Understanding 2,6-Difluoropyridine-3-boronic Acid: Properties and Synthesis

This compound typically presents as a white powder, with a purity often exceeding 99%. Its molecular formula is C5H4BF2NO2, and its molecular weight is approximately 158.90. The presence of both a difluorinated pyridine ring and a boronic acid group makes it highly versatile. It readily participates in various chemical transformations, including Suzuki-Miyaura cross-coupling reactions, making it a favored reagent for introducing complex molecular fragments. The synthesis typically involves reactions with 2,6-difluoropyridine and borate esters, often employing organolithium reagents under specific cryogenic conditions to achieve high yields and purity. As a supplier, ensuring reproducible synthesis protocols is key to maintaining product consistency.

Key Applications in R&D and Manufacturing

The primary utility of 2,6-Difluoropyridine-3-boronic acid lies in its role as a synthetic intermediate. It is extensively used in:

  • Pharmaceutical Drug Discovery: As a crucial building block for synthesizing Active Pharmaceutical Ingredients (APIs) and advanced drug candidates. Its structure can impart specific pharmacological properties.
  • Agrochemical Development: Contributing to the creation of novel pesticides and herbicides.
  • Materials Science: In the synthesis of specialized organic materials with unique electronic or optical properties.

When you are looking to buy 2,6-difluoropyridine-3-boronic acid for your projects, consider the specific purity requirements and the scale of your needs. Researching potential manufacturers and their quality control processes is an important step.

Sourcing from Reliable Manufacturers in China

China has emerged as a global hub for fine chemical manufacturing, offering a wide array of intermediates at competitive prices. For companies seeking to purchase 2,6-difluoropyridine-3-boronic acid, partnering with reputable Chinese manufacturers can provide significant advantages. These advantages include cost-effectiveness, substantial production capacities, and a growing emphasis on quality certifications such as ISO. When evaluating a 2,6-difluoropyridine-3-boronic acid supplier, look for clear product specifications, available COAs (Certificates of Analysis), and responsive customer service. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are dedicated to providing high-quality intermediates and robust support to their global clientele. Understanding the price of 2,6-difluoropyridine-3-boronic acid will involve comparing quotes from multiple verified suppliers to ensure you get the best value for your investment.

In conclusion, 2,6-Difluoropyridine-3-boronic acid is a high-value intermediate. By understanding its chemical nature and the strategic benefits of sourcing from experienced manufacturers, procurement professionals can ensure the success of their R&D and production initiatives.