For procurement managers in the pharmaceutical sector, securing a consistent and high-quality supply of chemical intermediates is a core responsibility. 2-Bromo-5-hydroxybenzaldehyde (CAS 2973-80-0), a crucial precursor for Crisaborole, requires careful sourcing to meet stringent industry standards. This guide outlines the key factors to consider when looking to buy this vital compound.

Why 2-Bromo-5-hydroxybenzaldehyde is Critical:

This specific benzaldehyde derivative plays an indispensable role in the synthesis of Crisaborole, a well-established topical treatment for atopic dermatitis. The molecule's structure, featuring bromine, a hydroxyl group, and an aldehyde, makes it a perfect starting point for complex organic transformations. As a buyer, ensuring the material you procure is precisely as specified is paramount for the downstream manufacturing process.

Key Procurement Factors:

  1. Quality Specifications: The most critical factor is purity. For pharmaceutical intermediates, a minimum purity of 98% is often required. Always request a detailed Certificate of Analysis (CoA) from potential suppliers. This document should confirm the purity, identify any known impurities, and state the analytical methods used (e.g., HPLC, GC). Understanding the physical form (solid) and appearance (e.g., white to brown powder) is also important for quality checks upon receipt.
  2. Supplier Vetting: When searching for a reliable manufacturer or supplier, consider their certifications (e.g., ISO, GMP compliance where relevant for intermediates), production capacity, and customer reviews. Suppliers based in China, like NINGBO INNO PHARMCHEM CO.,LTD., often offer competitive pricing and significant production volumes, making them attractive partners for bulk purchases. Look for suppliers who can provide comprehensive technical support and documentation.
  3. Pricing and Quotation: Obtaining multiple quotes is standard practice. Compare not only the per-unit price but also consider bulk discounts, payment terms, and any additional charges (e.g., for smaller quantities or expedited shipping). When requesting a quote, clearly state the required CAS number (2973-80-0), purity, quantity, and any specific packaging requirements. Using terms like 'price for 2-bromo-5-hydroxybenzaldehyde' or 'bulk purchase 2-bromo-5-hydroxybenzaldehyde' will help refine your search.
  4. Logistics and Lead Times: Understand the supplier's lead times for production and shipping. For ongoing manufacturing, a stable and predictable supply chain is essential. Inquire about shipping methods, costs, and any import/export regulations that might affect delivery.

Finding the Right Partner:

To efficiently procure 2-Bromo-5-hydroxybenzaldehyde, leverage online B2B platforms and direct manufacturer websites. Search terms like 'buy 2-bromo-5-hydroxybenzaldehyde,' 'pharmaceutical intermediate supplier,' or 'CAS 2973-80-0 for sale' will lead you to potential vendors. Prioritize suppliers who demonstrate transparency, a commitment to quality, and responsiveness to inquiries. NINGBO INNO PHARMCHEM CO.,LTD. is a manufacturer and supplier dedicated to meeting these requirements, offering high-purity 2-Bromo-5-hydroxybenzaldehyde backed by robust quality assurance and customer service.

By focusing on these procurement principles, pharmaceutical companies can ensure they acquire the necessary quantities of 2-Bromo-5-hydroxybenzaldehyde of the required quality, supporting their manufacturing operations and the development of critical medicines.