Procurement managers play a pivotal role in the pharmaceutical and biotechnology sectors, ensuring that research and development projects have access to the necessary high-quality chemical raw materials and intermediates. 6-O-Benzylguanine (CAS 19916-73-5) is one such compound, critical for various research applications, particularly in oncology and drug discovery. This guide is designed to assist procurement professionals in effectively sourcing this essential pharmaceutical intermediate.

Understanding the Product: 6-O-Benzylguanine (CAS 19916-73-5)

6-O-Benzylguanine, often referred to as O6-BG, is a specialized chemical compound with a significant application as a pharmaceutical intermediate and a research tool. Its primary function is to act as an inhibitor of the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT). By inhibiting MGMT, it can enhance the efficacy of certain chemotherapy drugs that damage DNA. This makes it invaluable for:

  • Oncology Research: Studying drug resistance mechanisms and developing more effective cancer treatments.
  • Drug Development: Serving as a key intermediate in the synthesis of potential new therapeutic agents.
  • Biochemical Studies: Investigating DNA repair pathways and cellular responses to genotoxic agents.

The correct identification of this compound relies on its CAS number, 19916-73-5. Always verify this number when requesting quotes or placing orders.

Key Considerations for Procurement:

When procuring 6-O-Benzylguanine, procurement managers should focus on several critical aspects to ensure the quality and reliability of the supply:

  1. Supplier Qualification: Partner with established manufacturers and suppliers known for their commitment to quality and customer service. Look for companies that specialize in pharmaceutical intermediates.
  2. Product Specifications & Purity: Clearly define the required purity level (e.g., 97% minimum, 98%, or 99%+) and ensure the supplier can consistently meet these specifications. Always request a Certificate of Analysis (CoA) for each batch.
  3. Regulatory Compliance: Verify that the supplier adheres to relevant quality management systems (e.g., ISO certification) and can provide necessary documentation such as Material Safety Data Sheets (MSDS).
  4. Pricing and Value: Obtain detailed quotes from multiple qualified suppliers. Consider not just the price per unit but also the overall value, including lead times, shipping costs, and payment terms.
  5. Lead Time and Supply Chain Reliability: Understand the supplier's production and delivery schedules to ensure uninterrupted supply for your research projects. A robust supply chain is crucial to avoid project delays.
  6. Technical Support: The availability of technical support from the supplier can be invaluable for addressing any queries regarding product application or handling.

Why Choose a China-Based Manufacturer?

China has become a global leader in chemical manufacturing, offering significant advantages for sourcing pharmaceutical intermediates like 6-O-Benzylguanine:

  • Cost-Effectiveness: Access to competitive pricing without compromising quality.
  • Large-Scale Production: Capacity to fulfill orders from small research quantities to bulk commercial needs.
  • Established Expertise: Years of experience in synthesizing and exporting complex chemical compounds.

When you are looking to buy 6-O-Benzylguanine, selecting a reputable China-based manufacturer means accessing these benefits. We are committed to being your trusted partner, providing high-quality pharmaceutical intermediates with efficient service.

For your procurement needs, please contact us to request a quote for 6-O-Benzylguanine (CAS 19916-73-5). We are equipped to meet your demands for this vital chemical, supporting your crucial research and development initiatives.