For procurement managers in the pharmaceutical and biotech sectors, sourcing critical raw materials and intermediates is paramount to the success of research and development projects. One such vital compound is 6-O-Benzylguanine (CAS 19916-73-5). As a leading manufacturer and supplier of pharmaceutical intermediates, we understand the stringent requirements for purity, reliability, and cost-effectiveness that our clients demand. This article delves into why sourcing high-purity 6-O-Benzylguanine from reputable Chinese manufacturers is a strategic decision for your R&D needs.

Understanding 6-O-Benzylguanine and its Importance

6-O-Benzylguanine (O6-BG) is a synthetic guanine derivative that functions as a potent inhibitor of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (MGMT). Its primary role in research is to chemosensitize cancer cells to alkylating agents, a crucial step in developing more effective anticancer therapies. Its CAS number, 19916-73-5, is a globally recognized identifier for this specific chemical entity.

The compound’s mechanism of action involves irreversibly inactivating MGMT, a key enzyme that repairs DNA damage. By blocking this repair pathway, O6-BG allows cytotoxic lesions induced by chemotherapy to persist, leading to cancer cell death. This makes it an indispensable research chemical for studies focused on oncology, drug resistance mechanisms, and the development of novel antineoplastic agents.

Why Source from a China-Based Manufacturer?

China has emerged as a global powerhouse in the chemical manufacturing industry, particularly for pharmaceutical intermediates. When you are looking to buy 6-O-Benzylguanine, partnering with a Chinese manufacturer offers several distinct advantages:

1. Cost-Effectiveness: Chinese manufacturers often provide competitive pricing due to economies of scale and efficient production processes. This allows research institutions and pharmaceutical companies to acquire high-quality materials at a more affordable price, optimizing R&D budgets.

2. High Production Capacity: For large-scale research projects or early-stage manufacturing, the capacity of Chinese chemical suppliers is often unmatched. They can meet demands ranging from grams for initial lab testing to kilograms for preclinical development.

3. Quality Assurance: Reputable Chinese manufacturers adhere to international quality standards. Certificates of Analysis (CoA), Material Safety Data Sheets (MSDS), and compliance with GMP guidelines are typically provided, ensuring the purity and integrity of the 6-O-Benzylguanine you purchase.

4. Established Supply Chains: Many Chinese chemical companies have well-developed export channels, ensuring timely delivery to clients worldwide. Understanding the importance of timely delivery for R&D projects, they prioritize efficient logistics.

Key Considerations When Purchasing 6-O-Benzylguanine

When you are ready to purchase 6-O-Benzylguanine, consider the following:

  • Purity: Ensure the product meets your specified purity requirements (e.g., 97% min, 98%, or 99%+). This is critical for reproducible experimental results.
  • CAS Number Verification: Always confirm the CAS number 19916-73-5 to ensure you are procuring the correct compound.
  • Supplier Reliability: Choose a supplier with a proven track record and positive customer testimonials. Look for manufacturers who offer technical support and detailed product documentation.
  • Pricing and Quotation: Request a formal quote from multiple suppliers to compare prices and terms of sale. Understanding the price structure for different quantities is also important.
  • Sample Availability: Many suppliers offer free samples for evaluation, which is an excellent way to assess product quality before committing to a larger order.

Your Trusted Partner for Pharmaceutical Intermediates

As a dedicated manufacturer and supplier of pharmaceutical intermediates, we are committed to providing researchers and procurement managers with high-quality 6-O-Benzylguanine (CAS 19916-73-5). We understand the critical nature of your work and strive to offer competitive prices, reliable supply, and comprehensive technical support. By choosing us as your supplier, you ensure that your drug discovery and research projects are supported by the finest chemical building blocks. Reach out to us today for a quote and to discuss your specific requirements for this essential pharmaceutical intermediate.