In the intricate world of chemical manufacturing and pharmaceutical development, the quality and availability of key intermediates are paramount. (E)-4-Hydroxycrotonic Acid (CAS: 24587-49-3), also known as 4-hydroxy-but-2-enoic acid, is one such compound that has garnered significant attention due to its versatility and essential role in various synthetic processes. This article aims to provide a detailed overview of its properties, applications, and the critical factors to consider when seeking to buy this compound from a reputable manufacturer or supplier.

Chemical Profile and Properties

(E)-4-Hydroxycrotonic Acid presents as a light yellow crystalline powder. Its molecular formula, C4H6O3, and molecular weight of 102.08900, reveal a relatively simple yet highly functional structure. Key physical and chemical properties that make it attractive for industrial applications include a high boiling point of 338.7ºC at 760 mmHg and a flash point of 172.9ºC, indicating good thermal stability and relative safety under controlled conditions. The assay purity is typically specified at a high level, ≥98.0%, ensuring its suitability for demanding synthesis tasks. These characteristics, combined with recommendations for storage in a cool, ventilated place, underscore its reliability as a chemical ingredient.

Versatile Applications in Synthesis

The primary application that highlights the importance of (E)-4-Hydroxycrotonic Acid is its role as a critical intermediate in the pharmaceutical industry, most notably in the synthesis of Neratinib (CAS: 698387-09-6), a potent drug used in oncology. Beyond this significant use, its structure, featuring both hydroxyl and carboxylic acid groups, makes it a valuable building block in a wide range of organic synthesis reactions. Researchers and chemists can leverage its reactivity to construct more complex molecules for various applications, including the development of novel APIs, agrochemicals, and specialty materials. This versatility makes it a sought-after commodity for companies engaged in chemical innovation.

Choosing the Right Supplier

When procuring (E)-4-Hydroxycrotonic Acid, selecting the right manufacturer or supplier is crucial for ensuring consistent quality, reliable delivery, and competitive pricing. Buyers should look for suppliers who:

  • Demonstrate High Purity: Verify that the product consistently meets the ≥98.0% assay specification.
  • Offer Technical Support: A good supplier will provide detailed technical data sheets and be responsive to inquiries.
  • Provide Stable Supply: Ensure the manufacturer has the capacity to meet your volume requirements, from R&D quantities to commercial batches.
  • Have Transparent Sourcing Practices: Understand where and how the intermediate is produced. Manufacturers in China, like NINGBO INNO PHARMCHEM CO.,LTD., offer robust production capabilities.
  • Offer Flexible Packaging: Customizable packaging, such as 25 kg drums, can be important for logistics and handling.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to being a premier supplier and manufacturer of (E)-4-Hydroxycrotonic Acid. We understand the exacting standards of the chemical and pharmaceutical industries and strive to provide exceptional quality and service. If you are looking to buy this essential intermediate, we invite you to contact us to discuss your specific needs and explore how our expertise can benefit your projects.