For procurement managers and R&D scientists in the pharmaceutical and fine chemical sectors, sourcing high-quality intermediates like (E)-4-Hydroxycrotonic Acid (CAS: 24587-49-3) is paramount. When looking to buy this crucial compound, understanding the landscape of manufacturers and suppliers, particularly in China, is essential. This article provides insights into what buyers should consider when selecting a reliable source for (E)-4-Hydroxycrotonic Acid, ensuring optimal quality and competitive pricing.

Understanding the Product: (E)-4-Hydroxycrotonic Acid

(E)-4-Hydroxycrotonic Acid, also known by its synonym 4-hydroxy-but-2-enoic acid, is a light yellow crystalline powder with a molecular formula of C4H6O3. Its primary significance lies in its role as a key intermediate in the synthesis of complex pharmaceutical compounds, most notably Neratinib (CAS: 698387-09-6), a targeted therapy used in cancer treatment. The assay purity of this intermediate is typically specified at ≥98.0%, a critical factor for downstream reaction efficiency and final product efficacy. High boiling point (338.7ºC) and flash point (172.9ºC) indicate its stability, which is a valuable trait for manufacturers and formulators.

The Appeal of Chinese Manufacturers

China has established itself as a powerhouse in the global chemical manufacturing industry, offering a vast network of producers capable of synthesizing a wide array of fine chemicals and intermediates. For (E)-4-Hydroxycrotonic Acid, Chinese manufacturers often provide advantages such as:

  • Scalability and Production Capacity: Chinese suppliers are equipped to handle both small-scale R&D orders and large-volume commercial production, ensuring a consistent supply chain.
  • Competitive Pricing: Due to economies of scale and efficient production processes, Chinese manufacturers can often offer more attractive price points for intermediates like (E)-4-Hydroxycrotonic Acid.
  • Quality Control: Reputable manufacturers adhere to international quality standards, ensuring that products meet the required purity and specifications. It is vital to partner with ISO-certified or GMP-compliant facilities.

Key Considerations for Procurement

When you are ready to purchase (E)-4-Hydroxycrotonic Acid, focus on these critical aspects to ensure a successful sourcing experience:

  • Purity and Specifications: Always confirm the assay purity (ideally ≥98.0%) and other critical specifications. Request a Certificate of Analysis (CoA) from the manufacturer.
  • Supplier Reliability: Look for established suppliers with a proven track record, good communication channels, and a commitment to timely delivery. Understanding their production capacity and lead times is crucial.
  • Regulatory Compliance: For pharmaceutical applications, inquire about the manufacturer's adherence to regulatory guidelines and the availability of supporting documentation.
  • Packaging and Storage: Ensure the product is packaged appropriately (e.g., 25 kg drums) to maintain its stability and quality during transit and upon arrival. Proper storage recommendations (cool, ventilated place) should be followed.
  • Requesting a Quote: When reaching out to a potential supplier, provide detailed information about your requirements, including the desired quantity, specifications, and delivery timeline. This will help them provide an accurate quote.

Finding a Trusted Supplier

NINGBO INNO PHARMCHEM CO.,LTD. stands as a prime example of a reliable Chinese manufacturer and supplier of (E)-4-Hydroxycrotonic Acid. We are dedicated to supporting the global pharmaceutical industry by providing high-quality intermediates. We encourage you to connect with us to discuss your specific needs for (E)-4-Hydroxycrotonic Acid. By partnering with us, you gain access to a dependable source that understands the importance of quality, consistency, and competitive pricing. Let us be your go-to manufacturer for this vital chemical intermediate and support your research and development efforts.