In the fast-paced world of pharmaceutical research, procuring the right chemical building blocks is paramount to success. JQ-1 Carboxylic Acid (CAS: 202592-23-2) has emerged as a vital intermediate, particularly for scientists engaged in developing Proteolysis Targeting Chimeras (PROTACs) that target BET (Bromodomain and Extra-Terminal) proteins. For procurement specialists and researchers, understanding the value and sourcing of this compound is essential.

The Significance of JQ-1 Carboxylic Acid in TPD

PROTACs represent a groundbreaking approach in drug discovery, utilizing the cell's own protein degradation machinery to eliminate disease-associated proteins. JQ-1 Carboxylic Acid plays a pivotal role as a 'warhead' or target ligand in PROTACs designed to inhibit BET proteins. These proteins are crucial epigenetic regulators, and their dysregulation is implicated in various diseases, including cancer. The carboxylic acid functional group on JQ-1 Carboxylic Acid provides a ready site for chemical modification, allowing it to be conjugated with linkers and E3 ligase ligands to construct functional PROTACs. This makes it an indispensable tool for researchers focusing on targeted protein degradation.

Key Factors for Buyers When You Buy JQ-1 Carboxylic Acid

When considering the purchase of JQ-1 Carboxylic Acid (CAS: 202592-23-2), buyers should focus on:

  • Purity Level: High purity, often specified as ≥97% or ≥98% by HPLC, is critical for reproducible research and successful PROTAC synthesis.
  • Supplier Credibility: Sourcing from established manufacturers and suppliers, particularly those based in China known for their chemical synthesis capabilities, can ensure quality and competitive pricing.
  • Application Relevance: Confirming its suitability as a BET bromodomain targeting moiety for PROTAC construction is key.
  • Technical Support: Access to technical data and customer support from the supplier can be invaluable.

NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier committed to providing high-quality pharmaceutical intermediates. We offer JQ-1 Carboxylic Acid, ensuring it meets the stringent requirements of TPD research. We invite you to contact us to inquire about pricing, bulk quantities, and to discuss your specific needs for this essential chemical intermediate.