In the rapidly evolving field of targeted protein degradation (TPD), Proteolysis Targeting Chimeras (PROTACs) have emerged as a revolutionary therapeutic modality. At the heart of PROTAC development lies the careful selection of molecular building blocks, and one such critical component is JQ-1 Carboxylic Acid (CAS: 202592-23-2). This article delves into the significance of this compound for researchers and procurement specialists looking to buy high-quality pharmaceutical intermediates.

What is JQ-1 Carboxylic Acid?

JQ-1 Carboxylic Acid is a derivative of the well-known BET bromodomain inhibitor, (+)-JQ1. Its chemical structure, featuring a carboxylic acid functional group, makes it an ideal 'warhead' for conjugation to linker molecules and E3 ligase ligands, thereby forming functional PROTACs. The BET (Bromodomain and Extra-Terminal) protein family plays a crucial role in gene regulation, and inhibiting their activity has shown promise in various therapeutic areas, including cancer and inflammatory diseases. JQ-1 Carboxylic Acid acts as a potent precursor for developing molecules that specifically target these BET bromodomains, leading to their selective degradation.

The Role in PROTAC Synthesis

The design of a PROTAC molecule typically involves three key components: a ligand that binds to the target protein (in this case, a BET bromodomain), a ligand that binds to an E3 ubiquitin ligase, and a linker connecting the two. JQ-1 Carboxylic Acid, with its inherent BET binding affinity and reactive carboxylic acid group, serves as an excellent starting point for the 'target protein' ligand. Researchers often seek to buy JQ-1 Carboxylic Acid from reliable suppliers in China to ensure consistent quality and availability for their synthesis efforts.

Key Features and Applications

When sourcing JQ-1 Carboxylic Acid (CAS: 202592-23-2), several factors are critical for researchers:

  • Purity: Typically, JQ-1 Carboxylic Acid is available with high purity, often exceeding 97% or 98% as determined by HPLC. This high purity is essential to avoid side reactions and ensure the efficacy of the synthesized PROTAC.
  • Chemical Stability: Proper storage conditions, often recommending a freezer at -20°C, help maintain its stability and efficacy.
  • Application in TPD: Its primary application is as a building block for PROTACs that target BET proteins, facilitating research in oncology, epigenetics, and other disease areas.

For procurement managers and R&D scientists, identifying a dependable manufacturer and supplier for JQ-1 Carboxylic Acid is paramount. The ability to secure this intermediate reliably, along with competitive pricing, directly impacts the pace and success of drug discovery programs.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying high-quality pharmaceutical intermediates like JQ-1 Carboxylic Acid. We understand the critical nature of these materials in advanced research and are committed to being a trusted partner for your chemical sourcing needs. Contact us to discuss your requirements for JQ-1 Carboxylic Acid and explore how we can support your groundbreaking research in targeted protein degradation.