For procurement managers and R&D scientists in the pharmaceutical and fine chemical sectors, the efficient sourcing of critical intermediates is paramount to project success and overall business operations. 2-Chloro-4-(chloromethyl)pyridine, a key pyridine derivative with CAS number 101990-73-2, is one such intermediate that demands careful consideration during the procurement process. This article provides a buyer's guide to help navigate the acquisition of this versatile compound, focusing on essential factors like purity, price, supplier selection, and its inherent application advantages.

Understanding the Product Specifications

Before initiating a purchase, it's vital to understand the key specifications of 2-Chloro-4-(chloromethyl)pyridine. Typically supplied as a pink liquid, its chemical formula is C6H5Cl2N, with a molecular weight of approximately 162.02 g/mol. The purity level is a critical factor; most industrial applications require a purity of 95% or higher, with 97-99% often preferred for pharmaceutical synthesis. Buyers should confirm the purity specifications with potential manufacturers. Additionally, understanding its physical properties, such as melting and boiling points, density, and flash point, is important for safe handling and storage. Reputable suppliers will readily provide detailed technical data sheets and safety information.

Key Factors in Supplier Selection

When looking to buy 2-Chloro-4-(chloromethyl)pyridine, selecting the right supplier is crucial for ensuring quality and reliability. Key considerations include:

  • Manufacturer Reputation: Opt for established manufacturers or distributors with a proven track record in producing and supplying chemical intermediates.
  • Quality Control: Verify that the supplier has robust quality control measures in place and can provide Certificates of Analysis (CoA) for each batch.
  • Supply Chain Reliability: Ensure the supplier can meet your volume requirements and maintain consistent supply, especially for ongoing projects. Sourcing from manufacturers in China often provides access to large-scale production capabilities.
  • Pricing and Payment Terms: Compare pricing across different suppliers and understand their payment and delivery terms. Inquiring about discounts for bulk purchases is advisable.
  • Customer Service and Technical Support: A responsive supplier that can offer technical assistance and address inquiries promptly is invaluable.

Application Advantages and Market Trends

2-Chloro-4-(chloromethyl)pyridine (CAS 101990-73-2) is highly valued for its dual reactivity, stemming from the chlorine atom on the pyridine ring and the chloromethyl group. This makes it a versatile building block for creating a wide range of pharmaceutical intermediates and APIs through reactions like nucleophilic substitution and cross-coupling. Its application in complex organic synthesis contributes to the development of novel therapeutic agents and specialty chemicals. The market for such intermediates is dynamic, with a consistent demand driven by the pharmaceutical industry's continuous pursuit of new drug candidates.

Procurement Strategies and Best Practices

For effective procurement, buyers should leverage online chemical marketplaces and directly contact manufacturers. Utilizing platforms that list suppliers and allow for price comparisons and quote requests can streamline the process. Offering free samples for initial evaluation is a common practice that allows buyers to assess product quality before committing to larger orders. When negotiating, focus on establishing long-term supply agreements with trusted manufacturers, particularly those in China known for their competitive pricing and production capacity for intermediates like 2-Chloro-4-(chloromethyl)pyridine.

In summary, the procurement of 2-Chloro-4-(chloromethyl)pyridine requires a systematic approach, focusing on product specifications, supplier reliability, and cost-effectiveness. By understanding these factors and leveraging the strengths of global manufacturers, businesses can secure a consistent and high-quality supply of this essential chemical intermediate, thereby supporting their critical R&D and production needs.