In the dynamic world of pharmaceutical development, the quality and availability of key intermediates are paramount. One such crucial compound is 2-Chloro-4-(chloromethyl)pyridine, identified by its CAS number 101990-73-2. This versatile heterocyclic compound serves as a foundational building block for a wide array of pharmaceutical agents and complex organic molecules. Understanding its properties and applications is essential for R&D scientists and procurement managers seeking reliable sourcing solutions.

Understanding 2-Chloro-4-(chloromethyl)pyridine (CAS 101990-73-2)

This chemical entity is a pyridine derivative characterized by the presence of two chlorine atoms—one at the 2-position and another at the 4-position—and a chloromethyl group also at the 4-position of the pyridine ring. These structural features impart significant reactivity, making it highly valuable in various synthetic pathways. Its physical form is often described as a pink liquid, with a molecular weight of approximately 162.02 g/mol. Key physicochemical properties, such as boiling point and density, are critical for handling and reaction optimization, with a reported boiling point of 51°C at 0.9 Torr and a density of 1.324 g/cm³.

Applications in Pharmaceutical Synthesis

The primary utility of 2-Chloro-4-(chloromethyl)pyridine lies in its role as a pharmaceutical intermediate. Its reactive sites—particularly the chloromethyl group—allow for nucleophilic substitution reactions, enabling the facile introduction of various functional groups. This makes it a cornerstone in the synthesis of Active Pharmaceutical Ingredients (APIs) across different therapeutic areas. Researchers leverage this compound to build complex molecular architectures, contributing to the discovery and development of new drugs. For instance, it can be used to synthesize pyridine-based heterocyclic compounds that form the core of many medicinal agents.

Key Considerations for Procurement

When looking to buy 2-Chloro-4-(chloromethyl)pyridine, several factors are crucial for B2B buyers. Firstly, ensuring the purity of the compound is essential for the success of your synthesis. Reputable manufacturers, especially those based in China, often provide detailed Certificates of Analysis (CoA) to verify purity levels. Secondly, supply chain reliability is vital. Partnering with a seasoned manufacturer or supplier ensures consistent availability, preventing production delays. Lastly, understanding the pricing structure and exploring bulk purchase options can lead to significant cost savings. Companies seeking to purchase this intermediate should look for suppliers that can offer competitive pricing and efficient logistics.

Sourcing from China: A Strategic Advantage

China has emerged as a global hub for chemical manufacturing, offering a vast array of high-quality intermediates at competitive prices. For 2-Chloro-4-(chloromethyl)pyridine, sourcing from established Chinese manufacturers provides access to efficient production capabilities and economies of scale. Companies can find reliable suppliers offering free samples and flexible packaging options to meet specific project requirements. Engaging with a trusted manufacturer in China for your 2-Chloro-4-(chloromethyl)pyridine needs can streamline your procurement process and support your R&D endeavors effectively.

In conclusion, 2-Chloro-4-(chloromethyl)pyridine is an indispensable tool for modern pharmaceutical synthesis. By understanding its chemical characteristics, applications, and strategic sourcing options, R&D professionals and procurement managers can ensure the successful development and manufacturing of vital pharmaceutical products. As a premier chemical manufacturer and supplier, we are dedicated to providing the high-quality intermediates you need to drive innovation.