For pharmaceutical companies and contract manufacturing organizations (CMOs), securing a consistent and high-quality supply of intermediates is paramount. (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide (CAS: 899809-61-1) is one such critical compound, primarily recognized for its role in the synthesis of Vorapaxar Sulfate. As a procurement manager or a research scientist, understanding the nuances of sourcing this specific chemical is crucial for project success. This article serves as a strategic guide to help you navigate the procurement process, focusing on key considerations when you look to buy this vital component.

The first step in acquiring (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide is identifying reliable manufacturers and suppliers. China has emerged as a global hub for fine chemical and pharmaceutical intermediate production, offering competitive pricing and robust manufacturing capabilities. When searching for an (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide supplier in China, it's essential to vet their experience, quality control systems, and production capacity. Look for suppliers who can provide comprehensive Certificates of Analysis (CoA) that detail crucial specifications such as purity (typically ≥98.0% for this compound), appearance (white powder), and residue on ignition (≤0.5%). These metrics are non-negotiable for pharmaceutical applications where even minor impurities can impact the final drug product’s safety and efficacy.

Understanding the chemical's properties is also vital. (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide, with its molecular formula C17H15NO2 and a molecular weight of 265.30700, possesses specific physical and chemical characteristics that influence its handling and use in synthesis. Its density of 1.215±0.06 g/cm³ contributes to its stability. For buyers, knowing these details helps in planning storage and reaction conditions. When you request a quote for (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide, ensure that the supplier can provide detailed technical data sheets and safety information (MSDS).

The role of this intermediate in the synthesis of Vorapaxar Sulfate cannot be overstated. Vorapaxar Sulfate is a platelet aggregation inhibitor used in patients with a history of myocardial infarction or peripheral artery disease. Therefore, the quality and stereospecificity of the (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide used directly impact the therapeutic outcome of the final drug. This underscores the importance of partnering with an (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide manufacturer that adheres to strict Good Manufacturing Practices (GMP) or equivalent quality standards, even for intermediates.

When negotiating the purchase of (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide, consider factors beyond just the price. Lead times, packaging options (often 25 kg drums or customized), and the supplier’s responsiveness to inquiries are equally important. Engaging with a reputable (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide producer in China often means gaining access to competitive pricing due to the country's manufacturing scale, but it also necessitates diligence in supplier qualification. By focusing on purity, consistency, and a reliable supply chain, pharmaceutical buyers can ensure the successful and efficient synthesis of critical medicines.