In the intricate landscape of pharmaceutical manufacturing, specialized chemical intermediates form the bedrock of life-saving medications. (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide, identified by its CAS number 899809-61-1, stands out as a compound of significant scientific and commercial interest. This white powder, characterized by its high purity (≥98.0%), plays a pivotal role as a building block in the synthesis of advanced pharmaceuticals, most notably Vorapaxar Sulfate. Understanding its properties and applications is key for professionals in the pharmaceutical and fine chemical industries looking to source this essential material.

The chemical identity of (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide, including its molecular formula C17H15NO2 and molecular weight of 265.30700, hints at a structure designed for specific synthetic pathways. Its physical characteristics, such as its appearance as a white powder and a density of 1.215±0.06 g/cm³, contribute to its manageability in industrial settings. Manufacturers in China are at the forefront of producing this intermediate, often adhering to stringent quality controls to ensure the low residue on ignition (≤0.5%) and high assay values that are critical for pharmaceutical-grade materials.

The primary application driving the demand for (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide is its use as a crucial intermediate in the production of Vorapaxar Sulfate. Vorapaxar is a protease-activated receptor-1 (PAR-1) antagonist that helps prevent thrombotic cardiovascular events. The synthesis of such a sophisticated therapeutic agent relies heavily on the precise stereochemistry and purity of its precursor compounds. The (R)-configuration of this intermediate is particularly important, ensuring the stereospecificity required for Vorapaxar’s biological activity and therapeutic efficacy.

For R&D scientists and product formulators, sourcing this intermediate from a dependable (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide manufacturer in China offers access to consistent quality. Pharmaceutical companies seeking to buy this compound can expect suppliers to offer detailed specifications, competitive pricing, and reliable delivery. The robust chemical manufacturing infrastructure in China supports the production of this and many other fine chemicals, making it an attractive region for sourcing essential pharmaceutical building blocks. Whether you are looking to purchase for bulk production or specialized research, partnering with a qualified supplier ensures the integrity of your drug development pipeline.

In essence, (R)-4-Hydroxy-N,N-diphenylpent-2-ynamide is more than just a chemical; it's an enabler of advanced pharmaceutical solutions. Its meticulous synthesis and stringent quality control are testaments to the sophisticated capabilities within the fine chemical sector. By understanding its significance and sourcing it wisely, researchers and manufacturers can continue to drive innovation in cardiovascular medicine.