In the realm of organic synthesis, the selection of appropriate intermediates is fundamental to achieving successful outcomes. 2-Bromo-3-fluorobenzonitrile, identified by its CAS number 425379-16-4, is a compound that has garnered significant attention due to its versatile chemical properties and wide-ranging applications in various scientific fields, including pharmaceutical development and materials science.

Physical and Chemical Characteristics: 2-Bromo-3-fluorobenzonitrile (C7H3BrFN, MW 200.01) is typically supplied as a solid, with a purity standard of 97% minimum. Its melting point is recorded in the range of 60.2-61.3℃, indicating it is a stable solid under ambient conditions. The compound exhibits a relatively high boiling point of 252.8℃ at 760mmHg, signifying good thermal stability during reactions that require elevated temperatures. Safety information, such as a flash point of 106.7℃, is also critical for proper handling in laboratory or industrial settings. Its density is approximately 1.69 g/cm³.

Chemical Reactivity and Synthetic Utility: The molecular structure of 2-Bromo-3-fluorobenzonitrile is key to its utility. It features three primary reactive sites: the nitrile group (-CN), the bromine atom (-Br), and the fluorine atom (-F) on the aromatic ring. The nitrile group can be transformed into various other functional groups, such as carboxylic acids, amines, or amides, through standard organic transformations like hydrolysis, reduction, or addition reactions. The bromine atom is particularly valuable as it serves as an excellent leaving group in palladium-catalyzed cross-coupling reactions. This enables chemists to introduce diverse carbon-carbon bonds (e.g., Suzuki, Stille, Heck couplings) or carbon-heteroatom bonds (e.g., Buchwald-Hartwig amination), allowing for the construction of complex molecular architectures. The presence of fluorine can also influence the electronic properties and biological activity of the final compounds, making it attractive for medicinal chemistry and agrochemical research.

Key Applications: The versatility of 2-Bromo-3-fluorobenzonitrile translates into numerous applications:

  • Pharmaceutical Intermediates: It is widely used as a building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for molecules requiring halogenated aromatic motifs.
  • Agrochemical Synthesis: The compound can serve as an intermediate in the development of new pesticides, herbicides, and other crop protection agents.
  • Materials Science: Its structure can be incorporated into functional materials, such as organic electronic components or specialty polymers.
  • Organic Synthesis Research: It is a valuable reagent for academic and industrial researchers exploring novel synthetic methodologies and creating complex organic molecules.

Sourcing and Purchasing: When looking to buy 2-Bromo-3-fluorobenzonitrile, it is recommended to source from reputable manufacturers and suppliers, such as NINGBO INNO PHARMCHEM CO.,LTD., who can guarantee high purity and provide comprehensive technical support. Inquiring about pricing, availability, and requesting samples are standard practices to ensure the best quality and value for your specific research or production needs.

In conclusion, 2-Bromo-3-fluorobenzonitrile stands out as a critical and versatile intermediate in the chemical industry. Its well-defined properties and reactivity make it an indispensable tool for chemists aiming to synthesize novel compounds for a variety of applications.