Fmoc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid, a specialized chiral building block, is an important reagent in modern synthetic chemistry, particularly within the realm of peptide and pharmaceutical research. Its unique structural features, combining an Fmoc-protected amino group with a benzothiophene moiety, offer distinct advantages for creating complex molecular architectures. This article delves into the key properties and applications of this compound, providing guidance for researchers looking to procure it from reliable suppliers and manufacturers.

The chemical identity of Fmoc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid is defined by its CAS number, 269396-51-2, and its typical appearance as a white to off-white solid or powder. With a standard purity of 97%, it is well-suited for applications where precise molecular structures are required. The Fmoc (9-fluorenylmethyloxycarbonyl) protecting group is a cornerstone in solid-phase peptide synthesis, allowing for controlled chain elongation. The benzothiophene group, a sulfur-containing heterocyclic aromatic ring system, introduces lipophilic and potentially pharmacologically relevant characteristics into the molecule.

The primary application of Fmoc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid lies in its use as a non-proteinogenic amino acid in the synthesis of peptides. These modified peptides can exhibit enhanced stability, altered biological activity, or improved pharmacokinetic properties compared to their natural counterparts. Medicinal chemists also employ this compound as a versatile building block in the synthesis of small molecule drug candidates, where the benzothiophene motif can contribute to binding affinity or modulate physicochemical properties.

For researchers and procurement specialists aiming to buy Fmoc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid, it is essential to identify manufacturers and suppliers known for their commitment to quality and purity. Reputable chemical suppliers ensure that each batch of Fmoc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid meets stringent specifications, providing researchers with the confidence needed for their sensitive synthetic procedures. Companies offering direct manufacturing capabilities often provide the most competitive pricing, especially for bulk orders, making them an excellent choice for continuous supply.

In conclusion, Fmoc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid is a valuable chemical intermediate with significant applications in peptide synthesis and drug discovery. By understanding its properties and sourcing it from trusted manufacturers and suppliers, researchers can effectively integrate this building block into their synthetic strategies, driving forward innovation in chemical and pharmaceutical sciences.