The field of peptide chemistry has seen remarkable advancements, driven by the availability of sophisticated building blocks that enable the synthesis of complex and functional peptides. Among these, non-proteinogenic amino acids have garnered significant attention for their ability to impart unique properties to peptide structures. Fmoc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid stands out as a key reagent in this domain, offering researchers a versatile tool for creating novel peptide sequences with tailored functionalities. This article explores its role and provides guidance on its procurement.

Fmoc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid (CAS: 269396-51-2) is characterized by its Fmoc-protected amine group and a side chain incorporating a benzothiophene ring attached via a propyl linker. This structure provides specific steric and electronic properties that can influence peptide conformation, receptor binding, and metabolic stability. The Fmoc group is integral to its application in solid-phase peptide synthesis (SPPS), allowing for stepwise addition of amino acids under mild conditions, a crucial aspect for maintaining the integrity of sensitive peptide chains.

The applications of Fmoc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid are diverse, primarily centering on its use in the construction of peptides for various research purposes. This includes the synthesis of peptidomimetics, modified peptides for therapeutic applications, and peptides used as ligands in biochemical assays. The presence of the benzothiophene moiety can introduce hydrophobicity, pi-stacking interactions, or serve as a site for further chemical modification, making it a valuable component for creating peptides with enhanced or novel biological activities.

For researchers and institutions looking to purchase Fmoc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid, identifying a dependable supplier is crucial. The standard purity specification is typically 97%, ensuring suitability for rigorous synthetic protocols. Partnering with manufacturers who specialize in peptide synthesis reagents guarantees access to high-quality materials. When inquiring about purchasing this compound, it is advisable to discuss bulk quantities with suppliers to secure competitive pricing and ensure a continuous supply for ongoing projects.

In summary, Fmoc-(R)-3-Amino-4-(3-benzothienyl)-butyric Acid is an essential non-proteinogenic amino acid derivative that significantly contributes to the advancement of peptide chemistry. Its unique structural features and compatibility with SPPS make it an indispensable tool for researchers. By sourcing from reputable manufacturers and suppliers, scientists can confidently acquire this vital building block to push the boundaries of peptide-based research and drug development.