In the pursuit of innovative pharmaceuticals and fine chemicals, understanding the properties and reliable sourcing of key intermediates is critical. 2-Cyano-5-Fluorobenzyl Bromide, identified by its CAS number 421552-12-7, is one such compound that holds significant value in chemical synthesis. This article provides a comprehensive overview of its properties, its primary applications, and guidance on how to effectively source this important chemical from manufacturers and suppliers, with a particular focus on those based in China.

Chemical and Physical Characteristics of 2-Cyano-5-Fluorobenzyl Bromide

2-Cyano-5-Fluorobenzyl Bromide is an organic compound with the molecular formula C8H5BrFN and a molecular weight of approximately 214.03 g/mol. Its structure features a benzene ring substituted with a cyano group (-CN), a fluorine atom (-F), and a bromomethyl group (-CH2Br). This combination of functional groups imbues the molecule with specific chemical reactivity, making it a valuable electrophilic agent in various synthetic pathways. Key physical properties often cited include:

  • Appearance: Typically described as a white to almost white solid.
  • Melting Point: Approximately 69 °C.
  • Boiling Point: Around 264.5 °C (predicted).
  • Solubility: Soluble in common organic solvents like methanol.
  • Sensitivity: Often noted as a lachrymator, indicating it can cause eye irritation.

These characteristics are essential for chemists and formulators to consider during handling, storage, and reaction planning.

Primary Applications and Significance

The most prominent application of 2-Cyano-5-Fluorobenzyl Bromide is its role as a crucial pharmaceutical intermediate. It is widely used in the synthesis of Trelagliptin, a DPP-4 inhibitor that plays a vital role in the treatment of type 2 diabetes. The demand for this anti-diabetic medication directly drives the market for its precursors. Furthermore, the unique chemical structure of 2-Cyano-5-Fluorobenzyl Bromide makes it a valuable organic building block for custom synthesis projects, potentially extending its use into other areas of fine chemical development, such as agrochemicals or specialized materials.

Sourcing from Chinese Manufacturers

For procurement managers and R&D professionals seeking to buy 2-Cyano-5-Fluorobenzyl Bromide, China offers a significant advantage due to its extensive chemical manufacturing capabilities. When looking for a reliable supplier, it is important to:

  • Verify Purity: Ensure the product meets the required purity standards (e.g., ≥98.0%) for your application.
  • Request Documentation: Obtain a Certificate of Analysis (CoA) and Safety Data Sheet (SDS) for quality assurance and safe handling.
  • Compare Pricing: Obtain quotes from multiple manufacturers to ensure competitive pricing.
  • Assess Reliability: Look for suppliers with a good track record of timely delivery and responsive customer support.

As a specialized manufacturer in China, we are committed to providing high-quality 2-Cyano-5-Fluorobenzyl Bromide, meeting the stringent demands of the pharmaceutical and fine chemical industries. We offer competitive pricing and reliable supply chains to support your research and production needs.

In summary, 2-Cyano-5-Fluorobenzyl Bromide is a compound of significant industrial and pharmaceutical relevance. Understanding its properties and leveraging strategic sourcing from capable manufacturers are key to successfully integrating it into your chemical synthesis processes.