For professionals in the pharmaceutical and fine chemical industries, securing high-quality intermediates is paramount to successful drug development and production. Among these critical compounds is 2-Cyano-5-Fluorobenzyl Bromide, identified by its CAS number 421552-12-7. This article aims to guide procurement managers and R&D scientists on effectively sourcing this essential chemical from reputable manufacturers and suppliers in China. Understanding its properties, applications, and the nuances of the supply chain can significantly impact your project's efficiency and cost-effectiveness.

Understanding 2-Cyano-5-Fluorobenzyl Bromide

2-Cyano-5-Fluorobenzyl Bromide is a key organic building block, particularly recognized for its role as an intermediate in the synthesis of Trelagliptin. Trelagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used in managing type 2 diabetes, highlighting the compound's importance in modern medicine. Its molecular structure, featuring a cyano group and a benzyl bromide moiety, equips it with the reactivity necessary for complex organic transformations, such as nucleophilic substitution reactions, which are fundamental in constructing intricate pharmaceutical molecules.

Key Properties and Applications

When looking to buy 2-Cyano-5-Fluorobenzyl Bromide, prospective buyers should pay close attention to its specifications. Typically, it presents as a white to off-white solid with a high purity, often specified as ≥98.0% via HPLC. This purity is critical for ensuring reliable and reproducible results in downstream synthesis, minimizing impurities that could compromise the final drug product. Beyond its primary use as a Trelagliptin intermediate, this versatile compound serves as a valuable building block in other fine chemical synthesis projects, contributing to advancements in various chemical research and development sectors.

Sourcing Strategies: Finding a Reliable China Manufacturer

China has emerged as a global hub for chemical manufacturing, offering a vast array of intermediates at competitive prices. For 2-Cyano-5-Fluorobenzyl Bromide, identifying a trustworthy manufacturer and supplier is key. When evaluating potential partners, consider factors such as:

  • Certifications: Look for ISO certifications and adherence to quality management systems.
  • Production Capacity: Ensure the supplier can meet your volume requirements, from R&D quantities to large-scale production.
  • Technical Support: A good supplier will offer technical data, safety information (SDS), and Certificates of Analysis (CoA).
  • Logistics: Understand their shipping capabilities, incoterms (FOB, CIF, EXW), and lead times.
  • Communication: Clear and responsive communication is vital for a smooth transaction and timely delivery.

For procurement managers seeking to purchase this pharmaceutical intermediate, engaging directly with manufacturers in China can lead to better pricing and direct quality control. Many Chinese suppliers specialize in custom synthesis and can offer tailored solutions to meet specific project needs.

Pricing and Market Trends

The price of 2-Cyano-5-Fluorobenzyl Bromide can fluctuate based on market demand, raw material costs, and purity levels. As the global incidence of type 2 diabetes continues to rise, the demand for Trelagliptin and its intermediates, including 2-Cyano-5-Fluorobenzyl Bromide, is expected to remain strong. Buyers should actively seek quotes from multiple suppliers to ensure they are obtaining the best possible price for this critical intermediate. For those looking to buy this chemical, comparing offers from various manufacturers will provide a clear picture of the current market value.

In conclusion, 2-Cyano-5-Fluorobenzyl Bromide (CAS 421552-12-7) is an indispensable component in the pharmaceutical supply chain. By understanding its properties and employing strategic sourcing methods from reputable China manufacturers, procurement professionals and R&D scientists can secure a reliable supply of this vital intermediate, facilitating the development and production of essential medications.