In the demanding fields of pharmaceuticals and fine chemicals, the purity of raw materials and intermediates is not merely a specification; it's a fundamental prerequisite for product efficacy, safety, and regulatory compliance. For 4-Chloro-4'-hydroxybenzophenone (CAS 42019-78-3), a crucial intermediate in the synthesis of APIs like Fenofibrate, adhering to stringent quality standards is paramount. As a dedicated manufacturer and supplier, Ningbo Inno Pharmchem Co., Ltd. places the highest emphasis on ensuring the purity and quality of this vital compound.

Understanding Purity Requirements

4-Chloro-4'-hydroxybenzophenone, with its molecular formula C13H9ClO2, is typically used in multi-step synthesis processes. The presence of impurities, even in trace amounts, can:

  • Interfere with downstream reactions: Impurities can act as catalysts or inhibitors, leading to unintended side reactions, lower yields, or entirely different products.
  • Contaminate the final API: If impurities are carried through the synthesis, they can lead to an API that fails to meet pharmacopoeial standards, rendering it unusable or even dangerous.
  • Complicate purification: Removing unwanted byproducts resulting from impure intermediates can significantly increase manufacturing costs and complexity.
  • Impact drug efficacy and safety: In the worst-case scenario, impurities can lead to reduced drug effectiveness or pose toxicological risks to patients.

This is why when you buy 4-Chloro-4'-hydroxybenzophenone, insisting on high purity, often specified as ≥99%, is essential.

Key Quality Indicators for 4-Chloro-4'-hydroxybenzophenone:

1. Assay (Purity):

This is the primary measure of the compound's concentration. For pharmaceutical applications, an assay of ≥99% is common. It is typically determined by techniques like High-Performance Liquid Chromatography (HPLC) or Gas Chromatography (GC).

2. Impurity Profiling:

Beyond the main compound, understanding the nature and levels of specific impurities is critical. Suppliers should be able to provide detailed information on known impurities, their origins, and their acceptable limits. This includes related substances, residual solvents, and heavy metals.

3. Analytical Methods and Documentation:

Reliable suppliers will use validated analytical methods and provide comprehensive Certificates of Analysis (CoA) for each batch. These documents should clearly state the test results against specifications. Familiarity with and adherence to pharmacopoeial standards (e.g., USP, EP) for related impurities is a strong indicator of quality.

4. Manufacturing Standards:

While not always GMP for intermediates, manufacturers operating under robust quality management systems, such as ISO 9001, demonstrate a commitment to process control and product consistency. This is a hallmark of trusted suppliers.

Choosing a High-Quality Supplier

When evaluating potential suppliers for 4-Chloro-4'-hydroxybenzophenone, always inquire about their quality control procedures, analytical capabilities, and documentation practices. As a leading manufacturer and supplier, Ningbo Inno Pharmchem Co., Ltd. is dedicated to providing 4-Chloro-4'-hydroxybenzophenone that meets the most demanding quality standards. We understand that your success hinges on the quality of the materials you purchase, and we are committed to delivering excellence with every order.