The advancement of modern medicine relies heavily on the availability of specialized chemical intermediates. Pyridine-3-sulfonyl Chloride (CAS: 16133-25-8) has emerged as a compound of considerable importance, primarily within the pharmaceutical sector. Its unique chemical structure and reactivity make it a key building block for the synthesis of various therapeutic agents, most notably Vonoprazan Fumarate.

Vonoprazan Fumarate is a novel potassium-competitive acid blocker that has shown significant promise in treating gastroesophageal reflux disease and other acid-related conditions. The synthesis of this API critically depends on the availability of high-purity Pyridine-3-sulfonyl Chloride. As a chemical intermediate, it functions as a sulfonylating agent, introducing the sulfonyl chloride moiety into the growing molecular chain. Ensuring a consistent supply from a reputable manufacturer is therefore paramount for companies developing or producing this drug.

When considering how to buy Pyridine-3-sulfonyl Chloride, attention must be paid to its specifications. Typically supplied as a colorless to yellow liquid with a purity of ≥99.0%, this compound requires specific handling due to its sensitivity to moisture. Suppliers often provide detailed Material Safety Data Sheets (MSDS) that outline proper storage and handling procedures, which are crucial for maintaining product integrity and safety in a laboratory or manufacturing setting.

The competitive price of Pyridine-3-sulfonyl Chloride can vary based on market demand, supplier, and order volume. It is recommended to obtain quotes from several established suppliers, particularly those based in major chemical manufacturing hubs like China, to ensure cost-effectiveness. The availability of such critical intermediates at competitive prices directly impacts the affordability and accessibility of life-saving medications.

In conclusion, Pyridine-3-sulfonyl Chloride is a foundational element in the synthesis of next-generation pharmaceuticals. Its role in creating drugs like Vonoprazan Fumarate underscores its significance. By understanding its properties and actively seeking out reliable manufacturers and suppliers, the pharmaceutical industry can continue to innovate and deliver essential treatments.