For any discerning buyer in the chemical and pharmaceutical industries, quality assurance is not just a procedural step; it's the bedrock of successful development and manufacturing. Tert-Butyl 4-aminobenzoate (CAS 18144-47-3), a key pharmaceutical intermediate and versatile chemical building block, is no exception. Ensuring the quality of this compound is paramount to achieving desired synthetic outcomes, regulatory compliance, and ultimately, product safety.

Key Quality Parameters for Tert-Butyl 4-Aminobenzoate

The most critical quality indicator for Tert-Butyl 4-aminobenzoate is its purity, typically specified as an assay of ≥99.0%. This high purity is essential to minimize the presence of impurities that could interfere with subsequent reactions, lead to unwanted byproducts, or compromise the efficacy and safety of the final pharmaceutical product. Impurities can arise from incomplete reactions during synthesis (e.g., residual starting materials like Tert-butyl 4-nitrobenzoate) or from degradation during storage.

Other important physical and chemical properties to consider include:

  • Appearance: White to light yellow to light orange crystalline powder. Deviations from this can indicate contamination or degradation.
  • Melting Point: Typically in the range of 108-110 °C. A melting point outside this range can suggest impurities.
  • Molecular Weight: 193.24 g/mol. This is a fundamental identifier.
  • CAS Number: 18144-47-3. Ensures you are sourcing the correct compound.

The Role of Documentation and Suppliers

Reputable manufacturers and suppliers of Tert-Butyl 4-aminobenzoate will provide comprehensive documentation to support their product's quality. The most crucial of these is the Certificate of Analysis (CoA). A CoA should detail the specific test methods used and the results for key parameters, including assay, impurity profile, melting point, and physical appearance. It serves as a tangible guarantee of the batch's quality.

When you seek to purchase Tert-Butyl 4-aminobenzoate, especially from manufacturers in China, it is vital to work with suppliers who offer transparent and detailed CoAs. Additionally, a Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) is essential for safe handling, storage, and transportation. It outlines potential hazards, first-aid measures, and protective equipment recommendations.

Ensuring a Reliable Supply Chain

Beyond the analytical data, the reliability of the supplier is a key component of quality assurance. A consistent supplier will have robust quality management systems in place, adhere to Good Manufacturing Practices (GMP) where applicable, and maintain consistent production processes. When procuring this API intermediate, inquire about the supplier's production scale, quality control procedures, and their ability to provide ongoing supply. For those looking to buy in larger quantities, discussing packaging options (e.g., 25kg/fiber drum) and storage recommendations (clean, dry, cool place, away from sunlight and rain) is also part of ensuring long-term product integrity.

In conclusion, obtaining high-quality Tert-Butyl 4-aminobenzoate requires a diligent approach. By focusing on essential quality parameters, demanding thorough documentation from suppliers, and partnering with reliable manufacturers, buyers can secure the necessary purity and consistency for their critical synthesis projects, whether in pharmaceutical development or broader chemical applications.