For professionals in the chemical and pharmaceutical industries, sourcing intermediates like 4-Hydroxy-3-nitrobenzonitrile (CAS 3272-08-0) is a critical task that directly impacts product quality and manufacturing efficiency. This compound, a vital precursor for Febuxostat, requires careful consideration during procurement. This guide offers insights into what to look for when sourcing this essential chemical, emphasizing quality, reliability, and the benefits of engaging with experienced suppliers.

4-Hydroxy-3-nitrobenzonitrile is a yellow powder with a defined purity of ≥98.0%. Its physical characteristics, such as a melting point of 146-148 °C and a density of 1.5±0.1 g/cm³, are key parameters to verify. When looking to buy this intermediate, it’s important to ensure that the supplier provides detailed Certificates of Analysis (CoA) that confirm these specifications. For pharmaceutical applications, consistency between batches is non-negotiable, making a supplier’s quality control system a primary consideration.

The primary application for 4-Hydroxy-3-nitrobenzonitrile is in the synthesis of Febuxostat, a drug essential for managing gout and hyperuricemia. The global demand for Febuxostat means that reliable access to this intermediate is crucial. Pharmaceutical companies often seek a 4-Hydroxy-3-nitrobenzonitrile supplier that can guarantee a stable supply chain, mitigate risks associated with raw material availability, and offer competitive Febuxostat intermediate price. This is where a robust network and efficient production capabilities become significant advantages.

China has established itself as a powerhouse in chemical manufacturing, offering a wide array of suppliers for intermediates like 4-Hydroxy-3-nitrobenzonitrile. When selecting a 4-Hydroxy-3-nitrobenzonitrile manufacturer in China, consider factors such as their experience in the pharmaceutical intermediate sector, their adherence to international quality standards (like ISO), and their capacity for large-scale production. It is also beneficial to inquire about packaging options, typically 25 kg drums, and their procedures for handling and shipping sensitive chemicals.

In conclusion, the successful sourcing of 4-Hydroxy-3-nitrobenzonitrile hinges on diligence and a focus on quality. By partnering with experienced and reputable 4-Hydroxy-3-nitrobenzonitrile suppliers, particularly those with a strong presence in China, companies can ensure the integrity of their supply chain and the quality of their final pharmaceutical products. This proactive approach to procurement is fundamental to success in the highly regulated pharmaceutical industry.