The chemical industry relies on a vast array of specialized compounds that serve as foundational elements for numerous applications. Among these, 4-Hydroxy-3-nitrobenzonitrile, designated by CAS number 3272-08-0, stands out as a key intermediate in the pharmaceutical sector. Its unique molecular structure and purity make it indispensable for the synthesis of Febuxostat, a significant medication used to treat gout. This article provides an in-depth look at the characteristics of 4-Hydroxy-3-nitrobenzonitrile and its importance in pharmaceutical manufacturing, highlighting why sourcing from reputable manufacturers is essential.

With a chemical name also recognized as 2-Nitro-4-cyanophenol or 3-nitro-4-hydroxybenzonitrile, this compound presents as a yellow powder. Its chemical formula, C7H4N2O3, and molecular weight of 164.118 g/mol are standard specifications for this organic molecule. Key physical properties include a density of 1.5±0.1 g/cm³, a melting point of 146-148 °C, and a flash point of 128.5±24.6 °C. These attributes are vital for handling, processing, and storage in industrial environments. The guaranteed assay purity of ≥98.0% ensures that it meets the high standards required for pharmaceutical intermediates, minimizing potential impurities in the final API.

The primary utility of 4-Hydroxy-3-nitrobenzonitrile is its function as a critical intermediate in the multi-step synthesis of Febuxostat. Febuxostat, a novel xanthine oxidase inhibitor, is instrumental in reducing uric acid levels in patients suffering from gout. The structural features of 4-Hydroxy-3-nitrobenzonitrile are strategically utilized in chemical reactions to build the complex molecular architecture of Febuxostat. Consequently, the demand for this intermediate is closely tied to the market performance and growth of Febuxostat. This connection makes sourcing from a reliable 4-Hydroxy-3-nitrobenzonitrile manufacturer crucial for pharmaceutical companies aiming for consistent production and timely market supply.

When seeking to purchase 4-Hydroxy-3-nitrobenzonitrile, particularly from China, it is important to select suppliers who can demonstrate a strong track record in quality control and production capacity. A dependable 4-Nitro-3-hydroxybenzonitrile supplier will offer detailed product specifications, batch consistency, and adherence to safety standards. The standard packaging is typically 25 kg drums, with flexibility for custom orders to suit specific client needs. For research scientists or procurement managers exploring options to buy 4-cyano-2-nitrophenol, understanding the supplier's reliability and product quality is the first step towards a successful collaboration.

In conclusion, 4-Hydroxy-3-nitrobenzonitrile is a high-value intermediate that plays a pivotal role in modern medicine. Its specific chemical properties and purity are fundamental to the successful synthesis of Febuxostat. By prioritizing partnerships with trusted 4-Hydroxy-3-nitrobenzonitrile manufacturers and suppliers, the pharmaceutical industry can ensure the continued availability of this essential compound, supporting the production of critical treatments for patients worldwide.