For pharmaceutical and fine chemical applications, the quality and purity of intermediates are paramount. 3-(2-Methoxy-5-methylphenyl)-3-phenylpropanoic acid (CAS 109089-77-2) is no exception. Ensuring that this compound meets stringent quality standards requires a clear understanding of its specifications and the analytical methods employed for its characterization. Reputable manufacturers prioritize these aspects to guarantee product integrity.

Key specifications for 3-(2-Methoxy-5-methylphenyl)-3-phenylpropanoic acid typically include its appearance (usually a white powder), its chemical purity (often specified as ≥99%), and its CAS number (109089-77-2). Suppliers should provide a comprehensive Certificate of Analysis (CoA) that details these parameters, along with any identified impurities and their levels. Understanding these specifications is vital for buyers to confirm the material's suitability for their intended synthesis or application.

To verify the quality of this intermediate, manufacturers employ a range of analytical techniques. High-performance liquid chromatography (HPLC) is commonly used to determine purity and quantify impurities, often employing reverse-phase columns with UV detection. Nuclear Magnetic Resonance (NMR) spectroscopy (¹H NMR and ¹³C NMR) is essential for confirming the chemical structure and identifying any structural isomers or residual starting materials. Mass Spectrometry (MS) is utilized to confirm the molecular weight and formula. Other techniques like Karl Fischer titration for moisture content and differential scanning calorimetry (DSC) for melting point determination are also standard.

When purchasing 3-(2-Methoxy-5-methylphenyl)-3-phenylpropanoic acid, it is advisable to ask potential suppliers about their analytical capabilities and request sample CoAs. This diligence ensures that the product you receive aligns with your project's requirements, minimizing risks and ensuring successful outcomes in your manufacturing or research endeavors. A focus on quality from the initial sourcing stage is a cornerstone of reliable pharmaceutical intermediate supply.