While 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine (CAS: 151266-23-8) is widely recognized as a pivotal intermediate in the synthesis of Ibrutinib, its utility extends into broader realms of pharmaceutical research and development. For medicinal chemists and R&D scientists, this versatile building block offers exciting possibilities for the discovery of novel therapeutic agents. As a chemical manufacturer focused on supporting innovation, we highlight the R&D potential of this compound.

Beyond Ibrutinib: Exploring New Therapeutic Frontiers

The pyrazolopyrimidine scaffold is a privileged structure in medicinal chemistry, appearing in numerous biologically active molecules. The specific functionalization of 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine, particularly the iodine atom, makes it an excellent substrate for various cross-coupling reactions, such as Suzuki, Stille, and Buchwald-Hartwig couplings. These reactions allow for the introduction of diverse chemical moieties, enabling the exploration of new chemical space and the synthesis of libraries of compounds for screening.

Key R&D Applications:

  • Lead Optimization: Researchers can utilize 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine to synthesize analogs of known drugs or to modify lead compounds, aiming to improve potency, selectivity, pharmacokinetic properties, or reduce toxicity.
  • Targeted Library Synthesis: Its reactivity makes it ideal for combinatorial chemistry approaches, generating diverse compound libraries for high-throughput screening against various biological targets, including kinases, enzymes, and receptors.
  • Discovery of New Kinase Inhibitors: Given its role in Ibrutinib (a kinase inhibitor), this intermediate can serve as a starting point for designing new inhibitors targeting other kinases implicated in diseases like cancer, inflammation, or autoimmune disorders. When looking to buy 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine for R&D, ensure high purity from a reliable chemical supplier.
  • Fragment-Based Drug Discovery: Smaller fragments derived from or incorporating the pyrazolopyrimidine core can be explored in fragment-based drug discovery campaigns.

Sourcing for Research: Quality Matters

For R&D applications, the quality and purity of 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine are paramount. Impurities can lead to erroneous results or complicate synthetic pathways. Therefore, it is crucial to purchase this intermediate from reputable manufacturers and suppliers who can guarantee high purity (e.g., ≥98.0% by HPLC) and provide comprehensive analytical documentation. Engaging with a dedicated pharmaceutical intermediate supplier ensures that your research efforts are built on a solid foundation.

We are committed to supporting innovation in drug discovery by providing high-quality chemical building blocks. If you are exploring new therapeutic avenues and require 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine for your R&D projects, we are your trusted partner for reliable supply and quality assurance.