Chloromethyl Carbonochloridate (CAS 22128-62-7) is a compound that chemists often encounter when working with acylations and the introduction of specific functional groups in organic synthesis. As a highly reactive acyl halide derivative of carbonic acid, its unique chemical properties make it a valuable tool for creating complex molecules, particularly in the pharmaceutical and fine chemical industries. Understanding its reactivity is fundamental for both academic researchers and industrial chemists seeking to leverage its potential.

At its core, Chloromethyl Carbonochloridate is characterized by a reactive carbonyl chloride group and a chloromethyl group. The carbonyl chloride moiety readily participates in nucleophilic acyl substitution reactions. This means it can react with alcohols to form carbonates, with amines to form carbamates, and with carboxylic acids to form mixed anhydrides. These reactions are foundational for building larger, more complex organic structures.

One of the most notable aspects of Chloromethyl Carbonochloridate's reactivity is its vigorous reaction with water. This hydrolysis liberates hydrochloric acid and carbon dioxide, alongside the formation of chloromethanol, which can further decompose. This characteristic necessitates its storage in dry, inert atmospheres and careful handling to avoid moisture contamination. For manufacturers and researchers looking to buy Chloromethyl Carbonochloridate, understanding these handling requirements is crucial for maintaining product integrity and ensuring safety.

The chloromethyl group also offers a site for nucleophilic displacement reactions, allowing for the introduction of the -CH2OCOCl group onto various substrates. This dual functionality – the reactive carbonyl chloride and the activatable chloromethyl group – makes it a versatile reagent for a wide array of synthetic transformations. For instance, it's employed in the preparation of prodrugs, where it can be used to attach a masked or esterified form of a drug molecule, improving its bioavailability or delivery characteristics.

When seeking to procure this compound, locating a reliable manufacturer is key. Companies that specialize in producing high-purity Chloromethyl Carbonochloridate, often specified with purity levels of ≥98%, are preferred. Whether one needs small quantities for laboratory research or bulk supply for industrial processes, finding a reputable supplier that can meet these demands is essential. This is especially true when considering specialized applications, such as its use as an intermediate for Metronidazole or Tenofovir synthesis, where consistent quality is non-negotiable.

The price of Chloromethyl Carbonochloridate can vary based on purity, quantity, and the supplier's location. For those in need of significant volumes, exploring options from manufacturers in regions like China can provide cost advantages. Accessing information on CAS 22128-62-7 from various sources helps in comparing offerings and ensuring a competitive purchase. Ultimately, harnessing the reactivity of Chloromethyl Carbonochloridate effectively in organic synthesis requires a combination of chemical knowledge, careful handling, and a reliable supply chain.