The field of chemical research constantly seeks novel compounds and building blocks that can unlock new possibilities in medicine, materials science, and beyond. 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine (CAS 6626-40-0) is a prime example of such a versatile molecule, offering significant potential for various research applications due to its unique heterocyclic structure.

A Versatile Heterocyclic Building Block

7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine, with its chemical formula C13H8Cl2N2O and molecular weight of 279.12, is characterized by a naphthyridine core functionalized with chlorine and methoxy groups. This combination of features makes it an attractive starting material for chemists aiming to synthesize more complex organic molecules. Its applications primarily stem from its role as a precursor in the pharmaceutical industry, notably in the development of antimalarial drugs like Pyronaridine.

Research Applications and Potential

Beyond its established use in Pyronaridine synthesis, researchers are exploring the potential of 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine in several areas:

  • Medicinal Chemistry: The naphthyridine scaffold is a privileged structure in medicinal chemistry, meaning it is frequently found in biologically active compounds. Researchers can modify this intermediate to create libraries of new derivatives that can be screened for various pharmacological activities, such as antimicrobial, antiviral, or anticancer properties. The electronegativity imparted by the chlorine atoms and the lipophilicity from the methoxy group can influence bioavailability and target interaction.
  • Organic Synthesis: As a highly functionalized heterocyclic compound, it serves as an excellent building block in advanced organic synthesis. Its reactive sites can be manipulated through various synthetic transformations to construct novel ring systems or introduce specific functional groups, leading to new classes of organic materials or complex natural products.
  • Materials Science: While less documented, heterocyclic aromatic systems can sometimes exhibit interesting electronic or photophysical properties. Further research might explore derivatives of this compound for applications in organic electronics, such as OLEDs or conductive polymers, although its primary focus remains pharmaceutical.

Sourcing for Research and Development

For academic and industrial researchers, obtaining reliable quantities of high-purity 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine is essential. Suppliers and manufacturers offering this compound, often with purity levels exceeding 95% (HPLC), play a crucial role in enabling these research endeavors. When looking to buy, researchers should seek suppliers who provide comprehensive technical data, including CoAs and SDS, and who can offer competitive pricing for laboratory-scale quantities.

Conclusion

7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine (CAS 6626-40-0) represents a valuable resource for the scientific community. Its established utility as a pharmaceutical intermediate, coupled with its potential in broader organic and medicinal chemistry research, highlights its significance. As research progresses, we can expect to see further innovative applications emerge from this versatile heterocyclic building block. For those involved in cutting-edge chemical research, securing this compound from a reputable manufacturer is a key step.