For professionals working with advanced organic compounds, a deep understanding of chemical properties and proper handling procedures is crucial. 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine, a key intermediate known by CAS number 6626-40-0, is one such compound that demands careful attention to its characteristics and storage requirements.

Chemical Profile and Specifications

7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine is a heterocyclic organic compound with the molecular formula C13H8Cl2N2O and a molecular weight of 279.12. Typically identified as a pale yellow solid, its structure features a naphthyridine backbone substituted with two chlorine atoms and a methoxy group. These substituents significantly influence its reactivity, solubility, and potential applications in organic synthesis.

Key properties reported for this compound include:

  • Melting Point: Approximately 186-187 °C, indicating a relatively stable solid form at room temperature.
  • Boiling Point: Around 434 ºC at 760 mmHg, though it is typically handled as a solid.
  • Density: Approximately 1.453 g/cm³.
  • Solubility: Sparingly soluble in chloroform, and slightly soluble in DMSO and methanol, often requiring heating for dissolution.
  • Purity: Manufacturers commonly provide it with a purity greater than 95% (HPLC), crucial for pharmaceutical applications.

Handling and Storage Recommendations

Due to its nature as a specialized chemical intermediate, proper handling and storage are essential to maintain its quality and ensure safety. The following guidelines are typically recommended by manufacturers and suppliers:

  • Inert Atmosphere: It is best stored under an inert gas, such as nitrogen or argon. This helps to prevent oxidation or degradation from atmospheric moisture and oxygen.
  • Temperature Control: Refrigerated storage, typically between 2-8°C, is advised. This controlled temperature environment helps preserve the compound's stability over time.
  • Safety Precautions: As with many organic chemicals, it should be handled with appropriate personal protective equipment (PPE), including gloves, eye protection, and lab coats. Consult the Safety Data Sheet (SDS) for detailed hazard information and handling procedures. Avoid inhalation of dust and direct skin contact.

Procurement Insights

When purchasing 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine, it is important to source from reputable manufacturers and suppliers who provide comprehensive technical data. Understanding the pricing structure based on quantity and purity is also key. If you are looking to buy this compound for your laboratory or production needs, contacting a trusted supplier for a quote is the first step.

Conclusion

A thorough understanding of the chemical properties and recommended handling procedures for 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine (CAS 6626-40-0) is vital for successful research and synthesis. By adhering to storage recommendations and safety protocols, and by sourcing from reliable manufacturers, users can ensure the integrity and efficacy of this important pharmaceutical intermediate.