The pharmaceutical industry's relentless pursuit of novel therapeutics relies heavily on the availability of specific, high-purity chemical intermediates. 1-(2-Chloropyridin-4-yl)ethanone, identified by CAS number 23794-15-2, stands out as a critical building block in this landscape. Its molecular structure and reactivity make it indispensable for synthesizing complex organic molecules, particularly those with therapeutic potential, positioning it as a key compound for drug discovery and development.

At its core, 1-(2-Chloropyridin-4-yl)ethanone serves as a precursor for a variety of sophisticated organic compounds. Its significance is amplified by its role in the synthesis of pyrimidine derivatives, a ubiquitous scaffold in many pharmacologically active molecules, including antivirals, antifungals, and anticancer agents. The presence of the chloro-substituted pyridine ring coupled with the acetyl group provides chemists with multiple points for functionalization and molecular elaboration.

A prime example of its importance is its application in the development of hSMG-1 inhibitors. These inhibitors are of considerable interest in oncology research due to their potential to modulate cellular processes relevant to cancer progression. The precise synthesis of these inhibitors often necessitates a reliable supply of pure 1-(2-Chloropyridin-4-yl)ethanone from trusted manufacturers. Pharmaceutical companies actively seek suppliers who can consistently deliver this intermediate at high purity levels (e.g., 97% or 99%) to ensure the efficacy and safety of their drug candidates.

The chemical synthesis of 1-(2-Chloropyridin-4-yl)ethanone itself involves multi-step organic reactions, often starting from more basic pyridine compounds. Manufacturers typically optimize these processes to achieve high yields and purity, employing techniques like column chromatography for purification. The resulting compound, a solid with a characteristic melting point, is then made available to the global market. For R&D scientists and procurement specialists, understanding these synthesis pathways can offer insights into potential impurities and the quality control measures employed by suppliers.

When considering purchasing 1-(2-Chloropyridin-4-yl)ethanone, buyers are encouraged to scrutinize the specifications provided by manufacturers. Beyond purity, details like molecular weight (155.58 g/mol) and elemental composition are critical. Furthermore, the safety data provided by suppliers is essential for proper handling and storage, ensuring compliance with laboratory and industrial safety regulations. The availability of this compound from suppliers in China, often at competitive prices, has made advanced drug discovery more accessible.

In conclusion, 1-(2-Chloropyridin-4-yl)ethanone is more than just a chemical compound; it is an enabler of critical advancements in medicine. Its role in synthesizing pyrimidine-based drugs and specialized inhibitors like those for hSMG-1 underscores its value in modern drug discovery. By partnering with reliable manufacturers and suppliers, researchers can ensure access to this vital intermediate, propelling the development of life-saving therapeutics forward.