For professionals in the chemical and pharmaceutical industries, understanding the detailed specifications of key intermediates is fundamental to successful procurement and application. 1-(2-Chloropyridin-4-yl)ethanone (CAS 23794-15-2) is a prime example of such a compound, where precise specifications dictate its suitability for various complex syntheses. This article aims to clarify these specifications and their implications for B2B customers looking to buy this versatile chemical.

The purity of 1-(2-Chloropyridin-4-yl)ethanone is arguably its most critical specification. Typically offered by manufacturers and suppliers in grades ranging from 95% to 99%, the choice of purity level directly impacts its intended use. For general organic synthesis or less sensitive reactions, a 95% grade might suffice. However, for advanced pharmaceutical intermediates, particularly in the synthesis of hSMG-1 inhibitors and other therapeutic agents, a purity of 99% is often mandated to ensure reaction specificity, yield, and the absence of unwanted byproducts that could compromise the final drug product's safety and efficacy. Buyers should always request and review the Certificate of Analysis (CoA) that details the exact purity and impurity profile.

Beyond purity, several physical and chemical properties are important. 1-(2-Chloropyridin-4-yl)ethanone is generally described as a solid, with its appearance ranging from off-white to brown. Its melting point is a key indicator of purity, typically falling within a specific range (e.g., 36-40°C as reported in some literature). The molecular formula C7H6ClNO and a molecular weight of approximately 155.58 g/mol are standard identifiers. These characteristics are crucial for chemists when designing reaction conditions and calculating stoichiometry.

The primary application driving the demand for 1-(2-Chloropyridin-4-yl)ethanone is its role as a pharmaceutical intermediate. Its specific chemical structure makes it ideal for building more complex molecules, including pyrimidine derivatives, which are foundational in many drug classes. Its use in the synthesis of hSMG-1 inhibitors highlights its strategic importance in the development of targeted cancer therapies. For R&D scientists, having access to a reliable supplier offering this compound with consistent specifications is essential for advancing their research pipelines.

Manufacturers and suppliers, particularly those based in China, play a significant role in making this intermediate accessible. When sourcing, B2B customers should look for suppliers who provide detailed technical data sheets, offer responsive customer service for inquiries regarding price and availability, and have robust quality control systems. Understanding the synthesis process and potential impurities can also aid in selecting the most appropriate supplier for specific project needs.

In conclusion, the specifications of 1-(2-Chloropyridin-4-yl)ethanone, especially its purity, are vital for its effective use in pharmaceutical synthesis and other applications. By carefully evaluating these specifications and working with reputable manufacturers and suppliers, businesses can ensure they procure a high-quality intermediate that meets their project's exacting demands, thereby facilitating innovation in drug discovery and chemical research.