In the intricate world of pharmaceutical synthesis, the selection and utilization of appropriate chemical intermediates are fundamental to developing effective and safe medications. 1-Amino-2-methylindoline Hydrochloride, identified by its CAS number 102789-79-7, stands out as a crucial building block, particularly in the synthesis pathway of Indapamide, a widely recognized diuretic and antihypertensive agent. Understanding its role and chemical significance is vital for chemists and formulators.

The primary significance of 1-Amino-2-methylindoline Hydrochloride (molecular formula C9H13ClN2, molecular weight 184.67) lies in its specific chemical structure, which allows it to be readily incorporated into the larger molecular framework of Indapamide. As a key intermediate, its purity and consistent quality directly impact the overall yield and efficacy of the final active pharmaceutical ingredient (API). Manufacturers specializing in fine chemicals and pharmaceutical intermediates play a critical role in providing this compound at the required high standards.

The synthesis of Indapamide often involves reactions where the amino group and the indoline ring structure of 1-Amino-2-methylindoline Hydrochloride are strategically utilized. Its light brown solid form and moderate solubility in solvents like methanol and chloroform facilitate its handling and reaction in standard organic synthesis laboratory settings. For R&D scientists, having access to reliable sources for this intermediate is essential for conducting thorough research and process development.

Beyond its direct application in Indapamide synthesis, this hydrochloride salt may also serve as a valuable starting material or intermediate in the exploration of other related pharmaceutical compounds or novel chemical entities. Its availability from reputable manufacturers and suppliers, often based in regions with strong chemical manufacturing infrastructure like China, ensures that researchers and production facilities can source it efficiently.

When procuring 1-Amino-2-methylindoline Hydrochloride, critical factors to consider include the supplier's commitment to quality control, adherence to safety protocols (as indicated by GHS hazard statements), and the provision of detailed technical data. Understanding the CAS number (102789-79-7) and ensuring the product meets stringent purity specifications are non-negotiable for pharmaceutical applications.

In conclusion, 1-Amino-2-methylindoline Hydrochloride is more than just a chemical compound; it is a vital cog in the machinery of modern pharmaceutical production. Its specific chemical properties and role in the synthesis of essential medicines like Indapamide underscore the importance of sourcing it from knowledgeable and reliable manufacturers. For any pharmaceutical company looking to purchase this intermediate, engaging with experienced suppliers for a quote is a necessary step to guarantee the quality and consistency of their end products.