For professionals in the pharmaceutical and fine chemical industries, a thorough understanding of key chemical intermediates is vital for successful R&D and manufacturing. 1-Amino-2-methylindoline Hydrochloride, identified by CAS number 102789-79-7, is one such compound, primarily recognized for its role as a synthetic intermediate in the production of Indapamide. This article aims to provide a detailed overview of its properties, applications, and the importance of sourcing it from reliable manufacturers.

Chemically, 1-Amino-2-methylindoline Hydrochloride (C9H13ClN2) is characterized by its molecular weight of 184.67. It typically presents as a light brown solid, with reported melting points exceeding 163°C with decomposition. Its solubility in common organic solvents like chloroform and methanol, although slight, is significant for its application in chemical synthesis. These physical and chemical properties make it a manageable and effective building block in complex organic reactions.

The primary application of 1-Amino-2-methylindoline Hydrochloride lies in its function as an intermediate for Indapamide, an important drug used for treating hypertension and edema. This makes it a crucial chemical for pharmaceutical companies engaged in the synthesis of cardiovascular and diuretic medications. Beyond this primary use, it may also find application in broader chemical research and development, potentially as a building block for other novel compounds.

Safety is a key consideration when working with any chemical. 1-Amino-2-methylindoline Hydrochloride is classified under the Globally Harmonized System (GHS) with hazard statements such as H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Precautionary statements like P261 (Avoid breathing dust/fume/gas/mist/vapours/spray) and P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing) highlight the need for careful handling and appropriate personal protective equipment (PPE).

For businesses looking to purchase 1-Amino-2-methylindoline Hydrochloride, identifying a reputable manufacturer and supplier is paramount. Suppliers based in China often offer competitive pricing and reliable quality. When making a purchase, inquire about product specifications, purity levels, and availability of necessary documentation like MSDS and CoA. Understanding storage conditions, typically recommended as -20°C in a freezer under an inert atmosphere, is also important for maintaining product integrity.

In summary, 1-Amino-2-methylindoline Hydrochloride is a critical pharmaceutical intermediate with well-defined chemical properties and important applications. Adhering to safety guidelines and choosing a trusted supplier are essential for successful procurement and utilization in pharmaceutical manufacturing. For those in need of this compound, contacting a qualified manufacturer for a quote is a vital step to ensure quality and availability.