The advancement of pharmaceutical sciences hinges on the availability of sophisticated chemical building blocks. Among these, indole derivatives play a significant role, and 1H-Indole-5-Carbonitrile, commonly known as 5-Cyanoindole (CAS 15861-24-2), stands out as a key intermediate. Its unique chemical structure and reactivity make it indispensable for the synthesis of a diverse range of active pharmaceutical ingredients (APIs). This article explores the critical role of this compound in modern drug manufacturing and highlights why sourcing high-purity material is essential for R&D success.

Understanding 1H-Indole-5-Carbonitrile (5-Cyanoindole)

5-Cyanoindole is an organic compound with the molecular formula C9H6N2. Its structure features an indole ring fused with a nitrile group at the 5-position. This combination provides multiple reaction sites, allowing for the creation of complex heterocyclic compounds that are frequently found in biologically active molecules. Typically appearing as an off-white crystalline powder, its high purity (often 98% or 99% assay) is a critical quality parameter for its use in pharmaceutical synthesis. As a pharmaceutical intermediate, it is not an end-product itself but a crucial component in the multi-step process of creating APIs.

Significance in Pharmaceutical Synthesis Pathways

The indole scaffold is a common motif in many therapeutically significant drugs. The presence of the nitrile group on 5-Cyanoindole offers a versatile handle for further chemical transformations, such as hydrolysis to a carboxylic acid, reduction to an amine, or participation in various cyclization reactions. This versatility makes it invaluable for medicinal chemists designing novel drug candidates. For instance, it can be utilized in the synthesis of:

  • Kinase Inhibitors: Many targeted cancer therapies involve small molecules that inhibit specific kinases, and indole structures are prevalent in these compounds.
  • Antiviral Agents: Certain antiviral drugs leverage the unique properties of indole derivatives.
  • CNS-Active Compounds: Molecules affecting the central nervous system often incorporate indole frameworks.

When researchers seek to buy 1H-Indole-5-Carbonitrile, they are looking for a reliable source that can guarantee the consistent quality and purity needed for sensitive synthetic steps. This is where reputable suppliers and manufacturers play a vital role.

Sourcing and Quality Assurance

Procuring 5-Cyanoindole requires careful consideration of the supplier. A trusted 5-Cyanoindole supplier should provide comprehensive documentation, including Certificates of Analysis (CoA) detailing the assay and impurity profile, as well as Safety Data Sheets (SDS). Partnering with a dedicated pharmaceutical intermediate manufacturer, especially one with experience in global supply chains, is highly recommended. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are equipped to meet these demands, offering high-purity materials with competitive pricing. For anyone investigating CAS 15861-24-2, understanding the supply chain and quality control measures of potential vendors is key to successful procurement.

In conclusion, 1H-Indole-5-Carbonitrile is a cornerstone intermediate in advanced pharmaceutical synthesis. Its structural features enable the creation of complex drug molecules, driving innovation in therapeutic development. Ensuring a reliable supply of high-purity material from qualified manufacturers is paramount for the success of any pharmaceutical R&D project.