In the dynamic field of drug discovery, the precise and efficient synthesis of novel molecular entities relies heavily on the availability of versatile chemical building blocks. 2,3-Dihydrobenzofuran-5-carbaldehyde, identified by CAS number 55745-70-5, is one such compound that has garnered significant attention among medicinal chemists and R&D scientists.

This organic aldehyde features a unique fused ring system, combining a benzene ring with a furan ring that has been reduced at the 2,3 positions. The presence of the aldehyde group at the 5-position makes it a highly reactive intermediate, amenable to a wide array of synthetic transformations. Its molecular formula, C9H8O2, and molecular weight of 148.16 g/mol are standard identifiers. Its utility extends across various synthetic strategies, enabling the construction of complex molecular architectures that are often found in bioactive compounds.

The significance of 2,3-Dihydrobenzofuran-5-carbaldehyde in drug discovery is underscored by its role as a precursor in the synthesis of pharmaceutical agents, most notably Ramelteon. Ramelteon, a melatonin receptor agonist, is prescribed for insomnia. The efficient synthesis of such drugs is critical for their commercial viability and accessibility to patients. Thus, securing a reliable supply of high-purity 2,3-Dihydrobenzo[b]furan-5-carbaldehyde is a priority for pharmaceutical manufacturers.

R&D scientists often require this compound for library synthesis, lead optimization, and structure-activity relationship (SAR) studies. The ability to modify the aldehyde group or the heterocyclic ring system allows for the exploration of diverse chemical space, potentially leading to the discovery of new therapeutic agents. When purchasing this intermediate, it is crucial to look for suppliers that guarantee high purity (e.g., ≥98.0% GC) and provide comprehensive product documentation, including technical data sheets and MSDS.

For research institutions and biotech companies, identifying reliable manufacturers and suppliers, particularly those based in regions like China known for robust chemical manufacturing, is essential. Exploring options to buy 2,3-Dihydrobenzofuran-5-carbaldehyde through established chemical distributors or directly from manufacturers can provide access to bulk quantities at competitive prices. Understanding market trends and engaging with experienced suppliers who can offer both standard and custom synthesis services will significantly benefit drug discovery programs.