In the intricate landscape of drug discovery and development, specific chemical intermediates serve as the bedrock upon which novel therapies are built. 2,4-Diamino-6-hydroxypyrimidine (CAS 56-06-4) is a prime example, recognized not only for its utility as a versatile pharmaceutical intermediate but also for its specific biological activity as a GTP cyclohydrolase I (GTPCH) inhibitor.

A Versatile Intermediate in Pharmaceutical Synthesis

The structural features of 2,4-Diamino-6-hydroxypyrimidine make it an ideal starting material or intermediate for synthesizing a variety of active pharmaceutical ingredients (APIs). Its pyrimidine core is a common motif in many biologically active molecules. As mentioned previously, it is crucial for producing drugs like:

  • Antifolate-M: A chemotherapy agent used in treating certain types of cancer.
  • Antihypertensive Drugs: Including compounds used to manage high blood pressure.
  • Folic Acid: Essential for cell growth and metabolism, its deficiency can lead to serious health issues.

For pharmaceutical companies involved in the research and development of these drug classes, securing a high-purity supply of this intermediate is vital. When you purchase this compound, you are investing in the foundation of your therapeutic innovation.

GTPCH Inhibition: A Tool for Biomedical Research

Beyond its role as a synthetic intermediate, 2,4-Diamino-6-hydroxypyrimidine functions as a specific inhibitor of GTP cyclohydrolase I. This enzyme is the rate-limiting step in the de novo synthesis of tetrahydrobiopterin (BH4), a critical cofactor for several enzymes, including those involved in nitric oxide (NO) production. Researchers utilize this inhibitory property to:

  • Investigate NO Pathways: By blocking BH4 synthesis, scientists can study the downstream effects on NO production in various cell models, contributing to research in cardiovascular health, inflammation, and neurological disorders.
  • Study Metabolic Pathways: Its use helps elucidate the complexities of pteridine metabolism and the regulatory mechanisms governing BH4 levels within cells.
  • Drug Target Validation: It can be used in preclinical studies to validate GTPCH or the BH4 pathway as potential therapeutic targets for diseases where dysregulation of these systems is implicated.

Procuring for Drug Discovery: What to Look For

When sourcing 2,4-Diamino-6-hydroxypyrimidine for drug discovery and development, researchers and procurement managers should prioritize suppliers that offer:

  • High Purity: Typically requiring ≥99.0% purity for reliable experimental results.
  • Availability in Research Quantities: Suppliers who offer smaller, research-oriented packaging sizes alongside bulk options are ideal.
  • Comprehensive Documentation: Access to MSDS, CoAs, and relevant safety information.
  • Competitive Pricing: Especially important for academic research or early-stage development budgets.

For businesses seeking a reliable source for this essential compound, our company, as a dedicated manufacturer and supplier, offers high-quality 2,4-Diamino-6-hydroxypyrimidine. We are equipped to meet your R&D and bulk manufacturing needs. Contact us today to buy or to get a quote.