In the intricate world of pharmaceutical synthesis, the quality and availability of key building blocks are fundamental to innovation and production. 3-Bromo-5-fluoropicolinonitrile (CAS 950670-18-5) stands out as a crucial intermediate, enabling the creation of complex molecules with therapeutic potential. For R&D scientists and product formulators, understanding its role and how to procure it effectively is vital. This article delves into the significance of this compound and provides insights for sourcing it from reliable chemical manufacturers.

Understanding 3-Bromo-5-fluoropicolinonitrile's Chemical Profile

3-Bromo-5-fluoropicolinonitrile, chemically known as 3-bromo-5-fluoropyridine-2-carbonitrile, is characterized by its pyridine ring structure substituted with bromine, fluorine, and a nitrile group. This unique arrangement makes it a highly reactive and versatile synthon in organic chemistry. Its molecular formula (C6H2BrFN2) and molecular weight (200.996) are standard identifiers. As a typical white to off-white crystalline powder, its physical form allows for straightforward handling in laboratory and industrial settings. The reported boiling point of 274.8±40.0 °C at 760 mmHg and a flash point of 120.0±27.3 °C provide important safety and processing parameters for potential buyers.

Applications in Pharmaceutical Development

The primary application of 3-Bromo-5-fluoropicolinonitrile lies in its role as a pharmaceutical intermediate. Its bromine and nitrile functionalities, coupled with the fluorinated pyridine core, offer multiple reaction sites for further chemical modifications. This makes it an invaluable starting material for synthesizing a wide array of Active Pharmaceutical Ingredients (APIs). For instance, it can be used in Suzuki couplings, nucleophilic aromatic substitutions, and other key C-C and C-N bond forming reactions essential for constructing complex drug molecules. Researchers often look to buy this compound when developing novel anti-cancer agents, antivirals, or central nervous system (CNS) drugs, where fluorinated heterocycles play a significant role in enhancing metabolic stability and bioavailability.

Sourcing Strategies and Supplier Importance

When seeking to purchase 3-bromo-5-fluoropicolinonitrile, identifying a dependable manufacturer is key. Companies specializing in fluorinated intermediates and pyridine derivatives are prime candidates. Buyers should prioritize suppliers that can guarantee high purity (≥98.0%) and provide comprehensive technical documentation, including safety data sheets (SDS) and certificates of analysis (CoA). For those looking for cost-effective solutions, exploring suppliers from China can be advantageous. Many Chinese chemical manufacturers offer this product for sale, with competitive pricing and the capability to handle bulk orders. It's advisable to request quotes for 3-bromo-5-fluoropicolinonitrile from multiple established suppliers to compare prices and service offerings.

Conclusion

3-Bromo-5-fluoropicolinonitrile is more than just a chemical compound; it's a gateway to new pharmaceutical innovations. Its unique chemical structure and reactivity make it indispensable in modern drug discovery and development. By understanding its properties and employing smart sourcing strategies, R&D scientists and procurement specialists can ensure access to this vital intermediate, driving forward the creation of life-saving medicines. If you are in need of this crucial pharmaceutical intermediate, consider reaching out to experienced manufacturers for a quote and to explore bulk purchase options.