As a leading manufacturer and supplier of fine chemicals, we witness firsthand the pivotal role certain intermediates play in driving scientific innovation. 3-Bromo-5-fluoropicolinonitrile (CAS 950670-18-5) is one such compound that has garnered significant attention, particularly within the pharmaceutical and agrochemical industries. Its unique structural features make it an exceptionally versatile building block for advanced organic synthesis. Here, we share our perspective on its chemical properties, its utility in complex syntheses, and why it is a sought-after product for researchers and formulators worldwide.

The Chemical Versatility of 3-Bromo-5-fluoropicolinonitrile

From a supplier's viewpoint, the demand for 3-Bromo-5-fluoropicolinonitrile stems from its inherent chemical reactivity. The presence of a bromine atom on the pyridine ring makes it an excellent substrate for cross-coupling reactions, such as Suzuki, Sonogashira, and Buchwald-Hartwig couplings. These reactions are foundational in constructing complex carbon-carbon and carbon-nitrogen bonds, which are ubiquitous in drug discovery and the development of new materials. The fluorine atom introduces electronic effects that can modulate the properties of the final molecule, impacting its stability, lipophilicity, and binding affinity. The nitrile group (C≡N) is also a highly reactive functional group that can be transformed into various other functional groups, including carboxylic acids, amines, and amides, further expanding its synthetic potential.

Key Applications in Advanced Synthesis

Our customers, primarily R&D scientists and product formulators, leverage 3-Bromo-5-fluoropicolinonitrile in several advanced synthetic pathways:

  • Pharmaceutical Intermediates: This is arguably its most prominent application. The compound serves as a critical starting material for the synthesis of numerous Active Pharmaceutical Ingredients (APIs). The fluorinated pyridine moiety is a common feature in many modern drugs due to its ability to enhance pharmacokinetic properties. Researchers frequently buy this intermediate to explore novel drug candidates.
  • Agrochemicals: Similar to pharmaceuticals, the structural features of 3-bromo-5-fluoropicolinonitrile are beneficial in designing new pesticides and herbicides with improved efficacy and environmental profiles.
  • Materials Science: The unique electronic and structural properties of fluorinated pyridine derivatives can also find applications in the development of specialized materials, such as organic light-emitting diodes (OLEDs) or conductive polymers, though these are more niche applications.

Ensuring Quality and Supply for Your Needs

As a manufacturer, we are committed to providing 3-Bromo-5-fluoropicolinonitrile with a purity of ≥98.0%, ensuring that our clients can proceed with their complex syntheses with confidence. We understand the importance of a consistent and reliable supply chain. For those looking to purchase this compound, whether for research purposes or larger-scale production, we encourage you to request a quote. Understanding your specific needs allows us to provide tailored solutions, including custom packaging and flexible delivery options. When you buy from us, you're not just acquiring a chemical; you're gaining a partner dedicated to supporting your innovation.

In conclusion, 3-Bromo-5-fluoropicolinonitrile is a testament to the power of thoughtfully designed chemical intermediates. Its rich reactivity and broad applicability make it an indispensable tool for chemists pushing the boundaries of scientific discovery. We are proud to supply this critical component and look forward to supporting your next breakthrough.