In the dynamic field of pharmaceutical research and development, the availability of high-quality chemical intermediates is fundamental to innovation and product success. 3-Pyridineacrylic Acid (CAS 19337-97-4) has emerged as a crucial compound, serving as a vital building block in the synthesis of a wide range of therapeutic agents. Understanding its chemical characteristics, applications, and how to procure it reliably is essential for pharmaceutical chemists and procurement professionals.

Understanding 3-Pyridineacrylic Acid: A Chemical Overview
3-Pyridineacrylic Acid, also known by synonyms such as Pyridine-3-acrylic acid or 3-(3-pyridyl)acrylic acid, is an organic compound with the molecular formula C8H7NO2 and a molecular weight of approximately 149.15 g/mol. It typically presents as a yellow crystalline powder, signifying a high degree of purity, often specified as 99% minimum. Its melting point, usually within the range of 232-235°C, indicates its solid form and thermal stability under standard laboratory conditions.

Key Applications in the Pharmaceutical Industry
The significance of 3-Pyridineacrylic Acid in pharmaceutical development is rooted in its versatile chemical structure, which allows for diverse synthetic transformations:

  • API Synthesis: It acts as a key intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs). Its pyridine nucleus and acrylic acid moiety provide reactive sites for constructing complex molecular architectures relevant to drug design.
  • Drug Discovery: Researchers utilize this compound in the discovery phase for novel drug candidates, particularly those targeting neurological disorders or possessing anti-inflammatory or anti-cancer properties, due to the favorable biological activity often associated with pyridine derivatives.
  • Organic Synthesis: As a functionalized building block, it plays a role in various organic reactions, enabling chemists to efficiently introduce specific structural elements into target molecules.
  • Agrochemical Development: Beyond pharmaceuticals, its structure holds potential for use in the agrochemical sector, possibly in the creation of new herbicides or plant growth regulators.

Procurement Best Practices for Pharmaceutical Buyers
For those looking to purchase 3-Pyridineacrylic Acid, especially for R&D or manufacturing purposes, a structured procurement approach is crucial:

  • Quality Assurance: Always verify the product's purity (minimum 99% is common) and obtain a comprehensive Certificate of Analysis (CoA) from the supplier. This document is critical for ensuring batch-to-batch consistency and compliance with regulatory standards.
  • Supplier Selection: Identify reputable manufacturers, preferably with strong chemical synthesis capabilities and a presence in major chemical supply regions like China. Companies with robust quality management systems and a commitment to regulatory compliance are preferred.
  • Pricing and Quotes: When seeking to buy, request detailed quotes specifying the quantity, purity, and delivery terms. Understanding the market price of 3-Pyridineacrylic Acid will help in effective negotiation.
  • Technical Support: A reliable supplier should be able to provide technical data, safety information (MSDS), and support for application-specific queries.

Leveraging Global Supply Chains
The global chemical market offers numerous options for sourcing 3-Pyridineacrylic Acid. Many manufacturers in China provide high-quality intermediates at competitive prices, supported by extensive production capacities and expertise. Establishing a relationship with a trustworthy supplier in this region can offer significant advantages in terms of cost, availability, and supply chain stability.

In conclusion, 3-Pyridineacrylic Acid (CAS 19337-97-4) is a cornerstone intermediate for the pharmaceutical industry. Its unique chemical properties and wide-ranging applications make it an indispensable compound for drug discovery and development. By focusing on quality, reliable suppliers, and strategic procurement, pharmaceutical companies can ensure a consistent supply of this vital chemical building block.