For research scientists engaged in advanced organic synthesis, the availability of versatile chemical building blocks is essential for pushing the boundaries of molecular design. 3-(Trifluoromethyl)phenylpropionic acid, identified by its CAS number 585-50-2, stands out as a compound with significant potential due to its unique structural features and reactivity. Its trifluoromethyl group and carboxylic acid functionality offer multiple avenues for chemical modification, making it a valuable asset in developing new synthetic methodologies and creating complex organic molecules.

Chemical Properties and Reactivity Profile

3-(Trifluoromethyl)phenylpropionic acid (C10H9F3O2) possesses a molecular weight of 218.17 g/mol. Its structure combines a phenyl ring substituted with a trifluoromethyl group at the meta position, connected to a propionic acid side chain. This combination imparts specific properties: the trifluoromethyl group enhances lipophilicity and electron-withdrawing characteristics, influencing the acidity of the carboxylic group and the reactivity of the aromatic ring. The carboxylic acid moiety is amenable to standard derivatization reactions, such as esterification and amidation, while the aromatic ring can undergo electrophilic aromatic substitution, though its reactivity is modified by the electron-withdrawing substituents.

Its low melting point (around 35°C) allows for flexible handling, transitioning easily between solid and liquid states. This ease of manipulation is advantageous in laboratory settings for reactions requiring precise addition or mixing.

Applications in Modern Organic Synthesis

One of the most significant applications of 3-(Trifluoromethyl)phenylpropionic acid is as a crucial intermediate in the synthesis of pharmaceuticals, most notably Cinacalcet. The trifluoromethylphenyl moiety is a critical component of the Cinacalcet molecule, contributing to its pharmacological activity and metabolic stability. R&D scientists working on drug discovery may use this compound as a starting point for synthesizing analogs or related compounds with potential therapeutic benefits.

Furthermore, the compound exhibits catalytic properties. It has been utilized in boron-catalyzed N-alkylation of amines with carboxylic acids. This capability positions it as a valuable reagent for researchers looking to streamline synthetic routes or develop novel catalytic systems. The specific electronic and steric environment provided by the trifluoromethylphenyl group can influence the selectivity and efficiency of these catalyzed reactions.

The molecule also serves as a versatile building block. Researchers can leverage its functional groups to introduce the trifluoromethylphenyl motif into a wide array of organic structures. This is particularly useful in the development of advanced materials, agrochemicals, or specialized research chemicals where fluorinated aromatic units are desired for their unique electronic or physical properties.

Research and Development Opportunities

The demand for high-quality 3-(Trifluoromethyl)phenylpropionic acid is driven by the continuous need for sophisticated intermediates in both academic and industrial research. Scientists can explore its reactivity in various coupling reactions, functional group transformations, and as a scaffold for combinatorial chemistry libraries. Its participation in enzyme-catalyzed reactions also opens avenues for biochemical studies and the development of biocatalytic processes.

For researchers seeking to buy 3-(Trifluoromethyl)phenylpropionic acid, partnering with a reliable supplier offering high purity material is essential. Access to detailed specifications, safety data, and reliable availability ensures that research projects can proceed without interruption. Many suppliers provide this compound in various grades and quantities, catering to needs from small-scale laboratory experiments to pilot-scale synthesis.

In conclusion, 3-(Trifluoromethyl)phenylpropionic acid (CAS 585-50-2) is more than just a pharmaceutical intermediate; it is a versatile tool for the modern synthetic chemist. Its unique combination of functional groups and the presence of the trifluoromethyl moiety make it an invaluable component in the synthesis of complex molecules, catalysis, and drug discovery research. For scientists looking to advance their projects, sourcing this high-quality compound from a dependable manufacturer is a strategic first step.