The journey from laboratory discovery to commercial pharmaceutical products is complex, relying heavily on specialized chemical intermediates. Among these, 2-Bromo-5-hydroxypyridine (CAS: 55717-45-8) stands out as a versatile and indispensable compound, particularly in the synthesis of Active Pharmaceutical Ingredients (APIs). Understanding its utility and ensuring a reliable supply chain are critical for success in drug development.

What is 2-Bromo-5-hydroxypyridine?

2-Bromo-5-hydroxypyridine, also known as 6-Bromo-3-pyridinol, is a substituted pyridine derivative. Its chemical structure (C5H4BrNO) makes it an excellent building block for creating more complex organic molecules. The bromine atom and the hydroxyl group provide reactive sites that can be manipulated through various chemical reactions, such as cross-coupling, nucleophilic substitution, and functional group transformations. This reactivity is key to its widespread use in medicinal chemistry.

Applications in Pharmaceutical Synthesis

The primary application of 2-Bromo-5-hydroxypyridine lies in its role as a pharmaceutical intermediate. It is a precursor in the synthesis of a wide range of therapeutic agents. Researchers utilize it to:

  • Synthesize Novel APIs: Its structure allows for the introduction of diverse functional groups and side chains, enabling the creation of new drug candidates targeting various diseases, including neurological disorders and inflammatory conditions.
  • Facilitate Cross-Coupling Reactions: As a brominated pyridine, it readily participates in Suzuki, Sonogashira, and Buchwald-Hartwig coupling reactions, which are cornerstone methodologies in modern pharmaceutical synthesis.
  • Develop Targeted Therapies: The pyridine core is a common scaffold in many bioactive molecules. The strategic placement of the bromine and hydroxyl groups allows for precise molecular modifications to enhance drug efficacy, reduce toxicity, and improve pharmacokinetic profiles.

The Importance of Sourcing Quality Material

Given its critical role in drug development, the purity and quality of 2-Bromo-5-hydroxypyridine are non-negotiable. Impurities can lead to side reactions, affect the yield of subsequent steps, and compromise the safety and efficacy of the final drug product. Therefore, it is crucial to buy this intermediate from a reputable manufacturer and supplier that guarantees high purity and consistent quality. Sourcing from a trusted entity, especially when looking to purchase in bulk, ensures that your production processes are robust and compliant.

Choosing a Trusted Manufacturer

NINGBO INNO PHARMCHEM CO.,LTD. serves as a premier supplier of 2-Bromo-5-hydroxypyridine (CAS: 55717-45-8) from China. We understand the stringent demands of the pharmaceutical industry and are dedicated to providing intermediates that meet exacting quality standards. Our commitment to purity, reliable supply, and competitive pricing makes us an ideal partner for your pharmaceutical research and manufacturing needs. If you are looking to buy high-quality CAS 55717-45-8 or require custom synthesis of related compounds, contact us for a quote and explore how we can support your next breakthrough.