Organic synthesis is the backbone of modern chemical innovation, driving advancements in pharmaceuticals, materials science, and agrochemicals. At the heart of many complex synthetic routes are carefully selected chemical intermediates, and 6-Bromo-4-hydroxyquinoline (CAS: 145369-94-4) stands out as a particularly versatile compound for R&D chemists.

Chemical Profile of 6-Bromo-4-hydroxyquinoline
This heterocyclic molecule, characterized by its quinoline framework, features a strategically placed bromine atom and a hydroxyl group. These functional groups make it an ideal starting material or intermediate for a multitude of chemical reactions. Typically supplied as a powder, its physical properties include a high melting point of approximately 283°C and moderate solubility in common organic solvents such as chloroform and methanol. These characteristics are essential for chemists designing reaction protocols, ensuring the compound integrates seamlessly into synthetic pathways.

Applications in R&D and Synthesis
Researchers frequently turn to 6-Bromo-4-hydroxyquinoline for its utility in building complex molecular architectures. In pharmaceutical research, it serves as a precursor for synthesizing drug candidates, where the quinoline moiety is often found in biologically active compounds. The bromine atom can participate in various cross-coupling reactions (e.g., Suzuki, Sonogashira), while the hydroxyl group can be derivatized or involved in other functionalization steps. This inherent reactivity allows for the introduction of diverse substituents, tailoring the final molecule's properties for specific applications.

For procurement professionals, the ability to buy 6-Bromo-4-hydroxyquinoline from reliable chemical suppliers is crucial. Ensuring a consistent supply of high-purity material is vital for reproducible experimental results and efficient scale-up. When searching for this compound, it’s important to look for suppliers who can provide detailed product specifications, including CAS number, purity levels, and safety data sheets (SDS).

Sourcing Strategies for Chemists
When planning your synthesis, consider the following when looking to purchase 6-Bromo-4-hydroxyquinoline:

  • Purity Matters: Aim for materials with purity levels of 98.0% or higher, as specified by GC or HPLC, to guarantee successful reaction outcomes.
  • Supplier Reputation: Partner with established chemical manufacturers and suppliers known for their quality control and customer service. Companies offering technical support can be invaluable resources.
  • Bulk vs. Research Quantities: Determine whether you need small quantities for initial R&D or larger batches for pilot studies. Many suppliers offer flexible packaging options.
  • Price and Lead Time: Obtain quotes from multiple manufacturers to ensure competitive pricing and understand lead times for delivery.

By understanding the chemical capabilities and sourcing strategies for 6-Bromo-4-hydroxyquinoline, chemists can effectively leverage this intermediate to drive innovation in their research projects. Engaging with trusted chemical suppliers, especially those with a strong presence in the global market, ensures access to this vital component for your advanced organic synthesis needs.