In the complex landscape of pharmaceutical research and development, the availability of high-quality chemical intermediates is foundational. 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one, with its CAS number 160129-45-3, stands out as a critical component in the synthesis of various therapeutic agents. This article delves into its significance as a chemical building block and the importance of reliable sourcing for drug discovery efforts.

Understanding the Chemical Structure and Properties

7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one is a heterocyclic organic compound characterized by a fused bicyclic system. Its molecular formula is C10H10ClNO, and it has a molecular weight of approximately 195.65 g/mol. Typically appearing as a yellow crystalline powder, it possesses a melting range of 95-105 °C. The compound's specific structural features, including the presence of a chlorine atom and a lactam ring, make it a versatile precursor for introducing specific functionalities into larger molecules during synthetic processes.

Key Applications in API Synthesis

The primary utility of 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one lies in its role as a direct intermediate for manufacturing Active Pharmaceutical Ingredients (APIs). A prominent example is its use in the synthesis of Tolvaptan. Tolvaptan is a selective V2 receptor antagonist used clinically to manage conditions like hyponatremia, a critical electrolyte imbalance. The efficient synthesis of Tolvaptan relies heavily on the quality and availability of this specific intermediate. Researchers and manufacturers looking to buy this compound are often driven by its direct applicability in creating high-value pharmaceutical products.

The Importance of Supplier Selection

For any scientist or procurement specialist involved in drug discovery and development, the choice of supplier for chemical intermediates like 7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one is a strategic decision. A reliable manufacturer will consistently provide material with guaranteed purity levels, often exceeding 99%, backed by comprehensive documentation such as Certificates of Analysis (CoA). This ensures that the intermediate meets the stringent requirements of pharmaceutical R&D and regulatory bodies. When you need to purchase this intermediate, prioritizing suppliers who demonstrate robust quality control and a stable supply chain is paramount to avoid disruptions in your research or production timelines.

Factors to Consider for Purchase

  • Purity and Specifications: Always verify the stated purity (e.g., ≥99.0% HPLC) and other critical parameters like assay, related compounds, and loss on drying.
  • Supplier Reliability: Opt for manufacturers with established experience in producing pharmaceutical-grade intermediates. Look for clear communication regarding lead times and shipping.
  • Technical Support: A good supplier may also offer technical support, assisting with any queries regarding the compound's properties or handling.
  • Pricing: Obtain quotes for your required quantities, considering both immediate needs and potential future bulk purchases.

Conclusion

7-Chloro-1,2,3,4-Tetrahydrobenzo[b]azepin-5-one is an indispensable chemical intermediate for modern pharmaceutical synthesis, particularly in the production of drugs like Tolvaptan. Its successful integration into complex synthesis pathways hinges on securing a consistent supply of high-purity material from reputable manufacturers. For R&D teams and pharmaceutical companies, strategically choosing a supplier for this compound is a critical step in accelerating drug discovery and ensuring the quality of manufactured APIs. If you're in the market to buy this essential intermediate, focus your search on suppliers that can guarantee quality and reliability.