The advancement of targeted cancer therapies has revolutionized patient care, offering more precise and effective treatment options. Central to the development of these sophisticated drugs are specialized chemical intermediates, meticulously crafted to ensure the efficacy of the final therapeutic. Among these, 2,5-Dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine, identified by CAS number 761440-16-8, stands out as a crucial building block for Ceritinib, a key player in treating specific forms of non-small cell lung cancer.

Understanding the Chemistry: What is 761440-16-8?

Chemically known as 2,5-Dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine, this compound features a pyrimidine core substituted with chlorine atoms and an isopropylsulfonylphenyl group. Its molecular formula is C13H13Cl2N3O2S, with a molecular weight of approximately 346.23 g/mol. Typically appearing as a white powder, its physical and chemical properties, such as a boiling point of 200°C and flash point of 112°C, are vital for safe handling and processing during chemical synthesis.

Ceritinib Synthesis: A Critical Link

Ceritinib (also known as LDK378) is a second-generation ALK inhibitor that has proven highly effective against ALK-positive NSCLC. The synthesis of Ceritinib involves a multi-step chemical process, and 2,5-Dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine serves as a pivotal intermediate in this pathway. Its unique structural features provide the necessary scaffold that, through subsequent chemical modifications, leads to the formation of the final, biologically active Ceritinib molecule.

Sourcing this Essential Intermediate

For pharmaceutical companies and contract research organizations (CROs) engaged in Ceritinib production or research, the reliable sourcing of 761440-16-8 is indispensable. When you search for a 2,5-Dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine manufacturer, look for suppliers who can guarantee high purity (≥98.0%) and consistent batch quality. Companies seeking to buy CAS 761440-16-8 often prefer to work with established suppliers in China due to competitive pricing and manufacturing capabilities.

The Importance of a Reliable Supplier

A trusted CAS 761440-16-8 supplier will not only provide the chemical but also offer essential documentation, such as Certificates of Analysis (CoA), and ensure adherence to safety protocols. If your project requires specific modifications or larger quantities, inquiring about custom synthesis 761440-16-8 services can be beneficial. The ability to get a competitive Ceritinib intermediate price from a reliable source directly impacts project timelines and overall manufacturing costs.

In summary, 2,5-Dichloro-N-(2-(isopropylsulfonyl)phenyl)pyrimidin-4-amine (CAS 761440-16-8) is more than just a chemical compound; it is a critical enabler of advanced cancer treatment. Its availability in high purity and reliable supply chains is crucial for pharmaceutical innovation.