Organic synthesis is the backbone of numerous industries, from pharmaceuticals and agrochemicals to materials science and specialty chemicals. At its core, it relies on a diverse toolkit of building blocks – reactive molecules that can be assembled into more complex structures. Among these essential components is 1-(2-Bromoethyl)-4-fluorobenzene (CAS 332-42-3), a fluorinated aromatic compound whose unique reactivity makes it a highly valued intermediate.

This article will shed light on the significance of 1-(2-Bromoethyl)-4-fluorobenzene in modern organic synthesis, its key applications, and how researchers and manufacturers can secure a reliable supply from expert suppliers.

Understanding the Chemical Profile of 1-(2-Bromoethyl)-4-fluorobenzene

1-(2-Bromoethyl)-4-fluorobenzene, also known by its common synonym 4-Fluorophenethyl bromide, possesses a distinct chemical structure that dictates its utility. The presence of a fluorine atom on the benzene ring influences electron distribution and can impart beneficial properties like increased lipophilicity and metabolic stability to the final synthesized products. The bromoethyl side chain provides a reactive site for a variety of nucleophilic substitution reactions, esterifications, and other transformations commonly employed in organic synthesis.

Key properties that make it a valuable building block include:

  • Reactivity: The primary bromide is an excellent leaving group, facilitating SN2 reactions.
  • Fluorine Substitution: The fluorine atom can influence regioselectivity and electronic properties of derivatives.
  • Versatility: It serves as a precursor to numerous functionalized ethylbenzene derivatives.

Applications Across Industries

The utility of 1-(2-Bromoethyl)-4-fluorobenzene (CAS 332-42-3) extends across several sectors:

  • Pharmaceutical Intermediates: This compound is vital for the synthesis of various Active Pharmaceutical Ingredients (APIs). It has been utilized in the development of compounds targeting the central nervous system (CNS), such as serotonin receptor modulators and other neurochemical agents. Its incorporation into drug molecules can enhance their pharmacokinetic profiles.
  • Agrochemicals: Similar to pharmaceuticals, the introduction of fluorine can improve the efficacy and stability of pesticides and herbicides. This intermediate can be a starting point for synthesizing such agrochemical compounds.
  • Materials Science: In advanced materials research, fluorinated aromatic compounds can contribute to the development of polymers, liquid crystals, and other functional materials with unique thermal and electronic properties.
  • Specialty Chemicals: It serves as a building block for a wide range of niche chemicals where specific structural features and reactivity are required.

For researchers and chemists looking to buy this compound, ensuring high purity (e.g., 97% or 99%) is critical to achieve reproducible results in their synthetic pathways.

Finding Reliable Suppliers for 1-(2-Bromoethyl)-4-fluorobenzene

The global demand for organic building blocks necessitates reliable sourcing strategies. Manufacturers and research institutions often look to specialized chemical suppliers and manufacturers, particularly those with strong capabilities in producing fluorinated aromatics and complex intermediates. Companies based in China have become prominent players in this market, offering:

  • Competitive pricing for bulk orders.
  • High-purity products (often with GC purity specifications).
  • Scalable production capacities to meet varying research and manufacturing needs.
  • Efficient logistics for international distribution.

When searching for a supplier for CAS 332-42-3, it is advisable to look for companies that provide:

  • Detailed product specifications and Certificates of Analysis (CoA).
  • Sample quantities for initial testing and validation.
  • Responsive customer service and technical support.
  • A commitment to quality and consistency in their manufacturing processes.

In conclusion, 1-(2-Bromoethyl)-4-fluorobenzene (CAS 332-42-3) is a fundamental building block in contemporary organic synthesis, enabling innovation across pharmaceuticals, agrochemicals, and materials science. By partnering with reputable manufacturers and suppliers, researchers can secure a consistent supply of this vital intermediate, driving their projects forward with confidence.