In the realm of pharmaceutical manufacturing, the precise selection and procurement of chemical intermediates are foundational to producing safe and effective medications. 3,4-Dihydroxy-5-nitrobenzaldehyde, a compound recognized by its CAS Number 116313-85-0, stands out as a critical intermediate, particularly in the synthesis of Entacapone. This article delves into the significance of this chemical, its applications, and the considerations for sourcing it as a reliable raw material for drug production.

The Chemical Profile of 3,4-Dihydroxy-5-nitrobenzaldehyde

3,4-Dihydroxy-5-nitrobenzaldehyde is a fine chemical characterized by its specific molecular structure, featuring reactive hydroxyl and nitro groups alongside an aldehyde functionality. These characteristics make it an ideal precursor for constructing complex organic molecules. Typically supplied as a fine powder, its appearance is often described as yellowish-green to yellowish-brown, with a purity assay usually above 99.0%. Its physical properties, such as melting point and solubility in solvents like methanol and ethanol, are well-documented by manufacturers, facilitating its integration into various synthetic processes. When you intend to buy this intermediate, understanding these properties is essential for successful formulation.

Key Role in Entacapone Synthesis

The primary industrial application driving the demand for 3,4-Dihydroxy-5-nitrobenzaldehyde is its indispensable role in the multi-step synthesis of Entacapone. Entacapone is a crucial drug used in the treatment of Parkinson's disease, working by inhibiting the enzyme catechol-O-methyltransferase (COMT) and prolonging the effect of levodopa. The structural features of 3,4-Dihydroxy-5-nitrobenzaldehyde provide the necessary molecular framework that, through a series of chemical transformations, leads to the final Entacapone API. For pharmaceutical companies involved in this synthesis, securing a consistent supply of this high-purity intermediate from a trusted manufacturer is vital for maintaining production schedules and product quality.

Sourcing and Supplier Considerations for Pharmaceutical Use

Procuring 3,4-Dihydroxy-5-nitrobenzaldehyde for pharmaceutical applications necessitates a rigorous selection process for suppliers. Manufacturers and distributors offering this compound must demonstrate a commitment to quality control and provide comprehensive analytical data. When seeking a supplier, particularly those in China known for chemical manufacturing, it is important to evaluate their production capacity, adherence to quality standards (e.g., ISO), and the availability of supporting documentation like Certificates of Analysis (COA) and MSDS. Building a relationship with a reliable supplier who can offer competitive pricing for bulk purchases ensures a stable supply chain, preventing disruptions in API production.

Beyond Entacapone: Research and Development

While Entacapone synthesis remains its primary application, 3,4-Dihydroxy-5-nitrobenzaldehyde also finds utility in research and development settings. It can be used as a reference standard for analytical method validation and impurity profiling within the pharmaceutical industry. Furthermore, its reactive functional groups make it a potential starting material for the synthesis of other novel compounds with possible therapeutic or industrial applications. For those looking to purchase for R&D purposes, identifying suppliers that cater to smaller, research-scale quantities while maintaining high purity is key.

In conclusion, 3,4-Dihydroxy-5-nitrobenzaldehyde is more than just a chemical intermediate; it is a critical component in the journey from raw material to life-changing medication. For any pharmaceutical company, understanding its properties and engaging with dependable manufacturers is the cornerstone of successful drug manufacturing.