3,4-Dihydroxy-5-nitrobenzaldehyde, identified by its CAS Number 116313-85-0, is a specialized organic compound that holds significant importance within the chemical and pharmaceutical industries. As a fine chemical intermediate, its primary value lies in its application as a crucial building block for the synthesis of more complex molecules, most notably Entacapone. Understanding its properties, synthesis, and application landscape is key for researchers, developers, and purchasers in the field.

Chemical Identity and Properties (CAS: 116313-85-0)

The chemical structure of 3,4-Dihydroxy-5-nitrobenzaldehyde features a benzaldehyde core substituted with two hydroxyl groups and a nitro group. This arrangement confers specific reactivity that makes it a valuable precursor. Available from various chemical manufacturers, it is typically presented as a yellowish-green to yellowish-brown powder with a high purity, often exceeding 99.0%. Its physical properties include a defined melting point, typically in the range of 134-145°C, and solubility in common organic solvents like methanol and ethanol. These characteristics are important for chemists when designing synthesis routes and handling the material.

Synthesis Pathways and Manufacturers

The synthesis of 3,4-Dihydroxy-5-nitrobenzaldehyde often begins with readily available starting materials such as 5-nitrovanillin. Various chemical routes have been reported, involving reactions like oxidation and subsequent functional group modifications. Chemical suppliers and manufacturers globally offer this compound, with a significant presence of suppliers based in China. When sourcing this chemical, it's advisable to look for suppliers who can provide detailed synthesis information or at least confirmation of their production capabilities. Direct engagement with a manufacturer can offer insights into product consistency and availability, allowing for informed purchase decisions.

Critical Applications in Pharmaceutical Synthesis

The paramount application of 3,4-Dihydroxy-5-nitrobenzaldehyde (CAS: 116313-85-0) is its role as an intermediate in the synthesis of Entacapone. Entacapone is a catechol-O-methyltransferase (COMT) inhibitor used in combination with levodopa and carbidopa for the management of Parkinson's disease. The specific arrangement of functional groups on the benzaldehyde derivative makes it ideally suited for constructing the Entacapone molecule. Beyond its primary use, this compound may also serve as a reference standard in analytical testing for Entacapone impurities or be employed in research for developing novel compounds with potential pharmacological activities. If you are seeking to buy this chemical for your research or production, ensuring you source from a reliable manufacturer is key.

Procurement and Supply Chain Considerations

For R&D scientists and procurement professionals, sourcing 3,4-Dihydroxy-5-nitrobenzaldehyde requires diligence. Understanding the CAS number 116313-85-0 is the first step. Next, identifying suppliers who can consistently deliver high-purity material is crucial. When looking to purchase, comparing prices from different manufacturers and verifying their ability to meet required specifications and quantities is standard procedure. Working with established chemical suppliers who understand the rigorous demands of the pharmaceutical sector ensures a smoother procurement process and a higher probability of receiving a quality product for your synthesis needs.