The Role of 4-Maleimidobutyric Acid in Modern Bioconjugation
In the intricate world of chemical synthesis and biological research, the ability to precisely link molecules together is paramount. This is where compounds like 4-Maleimidobutyric Acid shine. As a critical intermediate, it offers a unique combination of reactivity, enabling breakthroughs in fields ranging from pharmaceutical development to advanced material science.
4-Maleimidobutyric Acid, identifiable by its CAS number 57078-98-5, is characterized by its maleimide group and a terminal carboxylic acid. This bifunctional nature makes it an exceptionally useful linker. The maleimide moiety is renowned for its specific reactivity towards sulfhydryl (thiol) groups, forming stable thioether bonds through a Michael addition reaction. This specificity is invaluable when working with complex biological molecules like proteins, peptides, or antibodies, where precise modification is required.
The carboxylic acid terminus of 4-Maleimidobutyric Acid provides another anchor point for conjugation. It can be readily activated and coupled with primary amine groups to form robust amide bonds. This dual capability allows researchers to create sophisticated constructs, such as antibody-drug conjugates (ADCs) or bioconjugated nanoparticles, essential for targeted drug delivery and diagnostics. For those looking to buy this indispensable reagent, partnering with a reliable manufacturer ensures consistent purity and performance.
The applications of 4-Maleimidobutyric Acid extend into polymer chemistry, where it can be used to synthesize functionalized polymers with tailored properties. Its inclusion can enhance characteristics like adhesion, biocompatibility, or drug release kinetics in advanced materials. Procurement managers seeking cost-effective solutions will find that sourcing this chemical from established suppliers can significantly benefit their R&D budgets.
As a supplier, we understand the critical importance of quality. Our 4-Maleimidobutyric Acid is typically offered at high purity levels (≥97% or 98% by HPLC), ensuring reliable and reproducible outcomes in your sensitive applications. Whether you are developing novel therapeutics, diagnostic tools, or high-performance materials, our product can meet your stringent requirements. We encourage you to inquire about bulk pricing and partnership opportunities with us, your trusted manufacturer and supplier.
Perspectives & Insights
Core Pioneer 24
“This specificity is invaluable when working with complex biological molecules like proteins, peptides, or antibodies, where precise modification is required.”
Silicon Explorer X
“The carboxylic acid terminus of 4-Maleimidobutyric Acid provides another anchor point for conjugation.”
Quantum Catalyst AI
“It can be readily activated and coupled with primary amine groups to form robust amide bonds.”