Amoxicillin, a penicillin-class antibiotic, remains a cornerstone in the global fight against bacterial infections. Its widespread use necessitates a consistent and high-quality supply of its precursor materials. Among these, Methyl D-(-)-4-hydroxy-phenylglycinate, with CAS number 37763-23-8, plays a pivotal role as a key intermediate in the synthesis process. Understanding this compound's properties and its function is vital for pharmaceutical manufacturers and their suppliers.

Methyl D-(-)-4-hydroxy-phenylglycinate is an amino acid derivative that provides the essential side chain required for amoxicillin's biological activity. Its specific chiral configuration, denoted as D-(-), is critical for the correct stereochemistry of the final amoxicillin molecule, ensuring its effectiveness against a broad spectrum of bacteria. As a white to off-white solid, it possesses good solubility in polar solvents, facilitating its integration into various reaction pathways commonly employed in pharmaceutical synthesis.

The synthesis of amoxicillin typically involves coupling this glycinate derivative with a core beta-lactam structure. The ester group on the glycinate methyl ester is usually cleaved or modified during the subsequent steps. Pharmaceutical manufacturers seeking to buy this intermediate often look for suppliers who can guarantee high purity levels (≥99%) to ensure the efficiency and yield of the amoxicillin synthesis. The availability of this compound from reliable manufacturers in China, coupled with competitive pricing, makes it an attractive option for bulk purchasing.

When evaluating suppliers for Methyl D-(-)-4-hydroxy-phenylglycinate, considerations should extend beyond just the chemical itself. A supplier's adherence to quality management systems, such as ISO certifications, and their ability to provide detailed technical documentation, including Material Safety Data Sheets (MSDS) and Certificates of Analysis (CoA), are crucial indicators of reliability. For companies looking to secure their supply chain, engaging with established chemical suppliers who specialize in pharmaceutical intermediates, like NINGBO INNO PHARMCHEM CO.,LTD., offers a strategic advantage.

In essence, Methyl D-(-)-4-hydroxy-phenylglycinate is more than just a chemical compound; it is a critical enabler of one of the world's most important antibiotics. Its precise chemical structure, high purity, and reliable availability from trusted sources are fundamental to ensuring that amoxicillin continues to be accessible for global health needs.