The journey from a conceptual idea to a marketable drug is long and complex, heavily reliant on the precise synthesis of chemical compounds. Trans-N-Boc-1,4-Cyclohexanediamine (CAS 177906-48-8) has emerged as a significant intermediate in this process, offering unique structural advantages for drug discovery and development.

This compound, with its molecular formula C11H22N2O2 and a molecular weight of 214.30, is a white solid characterized by a cyclohexane ring featuring two amine groups in a trans configuration. One of these amine groups is protected with a tert-butyloxycarbonyl (Boc) group, a common and effective protecting group in organic chemistry. The Boc group is stable under many reaction conditions but can be readily cleaved using mild acidic treatment, revealing the free amine for further synthetic manipulation. This feature makes Trans-N-Boc-1,4-Cyclohexanediamine a versatile reagent for chemists.

In drug discovery, the precise construction of molecular architectures is key to developing compounds with specific biological activity and favorable pharmacokinetic properties. Trans-N-Boc-1,4-Cyclohexanediamine serves as an excellent building block for creating such complex molecules. Its diamine structure can be used to bridge different parts of a molecule, introduce conformational constraints, or serve as a scaffold for attaching various functional groups. For example, it is utilized in the synthesis of orally bioavailable and selective receptor antagonists, playing a crucial role in therapeutic research for conditions impacting fluid balance and cardiovascular health.

The importance of reliable sourcing cannot be overstated when dealing with intermediates critical for drug discovery. Researchers and procurement specialists often look to established manufacturers and suppliers, particularly those based in China, who can provide high-purity Trans-N-Boc-1,4-Cyclohexanediamine. A purity of 97% or higher is often preferred for demanding synthesis applications. When evaluating suppliers, checking for COAs and SDS documents is standard practice. The ability to buy in quantities ranging from grams for initial research to kilograms for pilot studies is also a critical consideration.

The trans configuration of the molecule is also significant, impacting how it interacts with other reagents and how the final synthesized compound folds in three-dimensional space. This stereochemical control is vital in medicinal chemistry, as enantiomers or diastereomers of a drug candidate can exhibit vastly different biological activities and safety profiles. Therefore, working with a supplier that guarantees the trans isomer is paramount.

In essence, Trans-N-Boc-1,4-Cyclohexanediamine is more than just a chemical; it's a tool that empowers innovation in drug discovery. By understanding its properties and leveraging the capabilities of global chemical manufacturers, research institutions and pharmaceutical companies can ensure they have the essential components needed to develop the next generation of medicines. For a dependable supply and competitive pricing, exploring options from experienced chemical suppliers is a wise strategy.